{"id":"W2749155133","doi":"10.1089/hgtb.2017.086","title":"Scalable Lentiviral Vector Production Using Stable HEK293SF Producer Cell Lines","year":2017,"lang":"en","type":"article","venue":"Human Gene Therapy Methods","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":107,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"FedDev Ontario","keywords":"Biology; Vector (molecular biology); Production (economics); Scalability; Viral vector; Cell culture; Computational biology; Virology; Biotechnology; Computer science; Genetics; Recombinant DNA; Operating system; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006728777,0.0002593923,0.0002248721,0.00005204369,0.001214712,0.0001919463,0.0003599979,0.0001480133,0.0001404912],"category_scores_gemma":[0.00009045297,0.0002308216,0.000169276,0.00005083931,0.0001397151,0.00002599488,0.0001757298,0.0001135161,0.00000876379],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002267279,"about_ca_system_score_gemma":0.00007895601,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001258459,"about_ca_topic_score_gemma":0.00001467042,"domain_scores_codex":[0.9982405,0.0003322726,0.0002485926,0.0006712771,0.0001454359,0.0003619575],"domain_scores_gemma":[0.9981984,0.000005846428,0.0002716312,0.001259832,0.0001658428,0.00009839435],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001275622,0.000195762,0.001652613,0.00002405338,0.00005404109,0.000001391753,0.00004787184,0.0002187079,0.9902911,0.000009845008,0.002580645,0.004796415],"study_design_scores_gemma":[0.000564323,0.0003025422,0.002866284,0.00001478606,0.00002190709,0.000008755721,0.00001422812,0.00005962612,0.9754773,0.0003912432,0.01997272,0.0003063201],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897586,0.003046913,0.004059566,0.00006169084,0.001316944,0.0003882398,0.000009523889,0.00003822682,0.001320293],"genre_scores_gemma":[0.959524,0.0004345026,0.02840349,0.0001083215,0.002526147,0.00006269381,0.00004385505,0.00007383972,0.008823123],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03023458,"threshold_uncertainty_score":0.9412632,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07821888694751518,"score_gpt":0.4049885298034152,"score_spread":0.3267696428559,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}