{"id":"W2749186582","doi":"10.1016/j.jmb.2017.08.007","title":"Studies on the Interaction of the Histone Demethylase KDM5B with Tricarboxylic Acid Cycle Intermediates","year":2017,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Versus Arthritis; Ministero dello Sviluppo Economico; Bayer HealthCare; Rosetrees Trust; Arthritis Research UK; Royal Society; Cancer Research UK; Ontario Ministry of Economic Development and Innovation; Genome Canada; Wellcome Trust; GlaxoSmithKline; Pfizer; Engineering and Physical Sciences Research Council; Eli Lilly and Company","keywords":"Demethylase; Tricarboxylic acid; Citric acid cycle; Histone; Chemistry; Biochemistry; Cell biology; Biology; Metabolism","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002686411,0.0004374322,0.0004044263,0.0001425696,0.0003002446,0.0001909686,0.0004463016,0.0003315485,0.0009885159],"category_scores_gemma":[0.0001508787,0.0001663538,0.0004167298,0.0002114994,0.0001577739,0.0001881473,0.0002361813,0.0004804493,0.0003776322],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007686192,"about_ca_system_score_gemma":0.0001724485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003089549,"about_ca_topic_score_gemma":0.002508283,"domain_scores_codex":[0.9998046,0.00003033672,0.000009614652,0.0000484329,0.00006041723,0.00004665156],"domain_scores_gemma":[0.9999368,0.00001231048,0.00001419462,0.000005049974,0.00001353565,0.00001800295],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002192665,0.00007792299,0.0008364235,0.0001872517,0.00006072898,0.00007655346,0.00004411513,0.000514738,0.9931284,0.0002642589,0.0001335959,0.004456717],"study_design_scores_gemma":[0.00001602873,0.0004064127,0.005643014,0.00001178442,0.0000376417,0.0002166176,0.00004734872,0.002684517,0.98079,0.00005012749,0.01008344,0.00001302287],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9687635,0.02082911,0.005896139,0.0003027722,0.00004638081,0.00004565856,0.0006167602,0.00006541117,0.003434222],"genre_scores_gemma":[0.9854295,0.005382949,0.00402822,0.000127332,0.0000084393,0.00001757484,0.001325343,0.00001281205,0.003667709],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003089549,"threshold_uncertainty_score":0.006143153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02174176524597921,"score_gpt":0.3417171779277366,"score_spread":0.3199754126817574,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}