{"id":"W2749229356","doi":"10.1093/neuros/nyx248","title":"Advances in Genomics Explain Medulloblastoma Behavior at the Bedside","year":2017,"lang":"en","type":"article","venue":"Neurosurgery","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; SickKids Foundation","funders":"","keywords":"Medulloblastoma; Atypical teratoid rhabdoid tumor; Medicine; Sonic hedgehog; Wnt signaling pathway; Smoothened; PTCH1; Oncology; Ependymoma; Brain tumor; Bioinformatics; Pathology; Cancer research; Internal medicine; Hedgehog signaling pathway; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005543444,0.0005441264,0.0005510198,0.0009283425,0.0004125302,0.001271881,0.0007751394,0.001429263,0.00547474],"category_scores_gemma":[0.001714508,0.0002545791,0.000486309,0.0005842725,0.001073766,0.002483755,0.0009282305,0.001782996,0.002179788],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001318694,"about_ca_system_score_gemma":0.0007741636,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003433645,"about_ca_topic_score_gemma":0.003023756,"domain_scores_codex":[0.999769,0.0000354125,0.00001257701,0.00007987989,0.00005458594,0.00004846698],"domain_scores_gemma":[0.9995913,0.000118462,0.00009779761,0.00004451244,0.00008817642,0.00005979371],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005135566,0.0002365495,0.1205706,0.001189091,0.0003443988,0.01176208,0.001852976,0.004975656,0.03740812,0.2097078,0.06650075,0.5449384],"study_design_scores_gemma":[0.00006310182,0.0003038997,0.1404379,0.001507557,0.0003164084,0.02504683,0.001994124,0.01201396,0.01145113,0.3092575,0.4974487,0.0001588663],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.2115773,0.4085782,0.1083038,0.1399707,0.004136122,0.0002137043,0.004218068,0.002666606,0.1203356],"genre_scores_gemma":[0.73331,0.199549,0.02946932,0.01485213,0.005900622,0.000115994,0.002131802,0.0005864345,0.01408466],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00547474,"threshold_uncertainty_score":0.01831484,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01347392763703835,"score_gpt":0.2756909843443922,"score_spread":0.2622170567073538,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}