{"id":"W2749229356","doi":"10.1093/neuros/nyx248","title":"Advances in Genomics Explain Medulloblastoma Behavior at the Bedside","year":2017,"lang":"en","type":"article","venue":"Neurosurgery","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; SickKids Foundation","funders":"","keywords":"Medulloblastoma; Atypical teratoid rhabdoid tumor; Medicine; Sonic hedgehog; Wnt signaling pathway; Smoothened; PTCH1; Oncology; Ependymoma; Brain tumor; Bioinformatics; Pathology; Cancer research; Internal medicine; Hedgehog signaling pathway; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001608187,0.0001090558,0.0001056425,0.000017167,0.0002605631,0.00004595823,0.0002586367,0.00005602013,0.00001909182],"category_scores_gemma":[0.00012708,0.00008587043,0.00008171074,0.00001752677,0.0001128633,0.000006486866,0.000181203,0.00007939006,0.00001321298],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000210401,"about_ca_system_score_gemma":0.00004732241,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002592669,"about_ca_topic_score_gemma":0.0005023723,"domain_scores_codex":[0.9992375,0.00003677654,0.0001670576,0.0002620679,0.00009591701,0.0002006921],"domain_scores_gemma":[0.9991505,0.00002281786,0.0001158038,0.0006523874,0.00001837814,0.00004007676],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001333034,0.00006878851,0.1117342,0.00001643071,0.000005943916,0.00005010292,0.00005001945,0.001004966,0.8319507,0.00001175521,0.004195504,0.05077829],"study_design_scores_gemma":[0.0008288707,0.0001066642,0.1370305,0.00004553809,0.00002609481,0.0001356401,0.00005718214,0.0005783783,0.5003368,0.00007923821,0.3602652,0.0005099816],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964409,0.001413572,0.00002546704,0.0002390326,0.0005401823,0.00009703656,0.00001182438,0.000007871992,0.001224146],"genre_scores_gemma":[0.996762,0.0017703,0.00003276637,0.00036425,0.0001969014,0.00005273264,0.00001434133,0.00002052348,0.0007862255],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3560697,"threshold_uncertainty_score":0.3501695,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01347392763703835,"score_gpt":0.2756909843443922,"score_spread":0.2622170567073538,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}