{"id":"W2749339960","doi":"10.1038/s41598-017-10972-0","title":"Novel quinolone chalcones targeting colchicine-binding pocket kill multidrug-resistant cancer cells by inhibiting tubulin activity and MRP1 function","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Laurentian University; Health Sciences North","funders":"Queen's University; University of California, San Francisco; Northern Ontario Heritage Fund Corporation","keywords":"Chalcone; Colchicine; Paclitaxel; Tubulin; Multiple drug resistance; Vinblastine; Cancer cell; Pharmacology; Cancer; Cancer research; Chemistry; Biology; Drug resistance; Microtubule; Cell biology; Microbiology; Chemotherapy; Stereochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.001319434,0.0002608642,0.0003652446,0.00004951848,0.001873542,0.0006159387,0.0001626199,0.0001964314,0.0003491791],"category_scores_gemma":[0.000656261,0.0002055393,0.0001017717,0.00007781424,0.0004239564,0.0003597427,0.0002655074,0.0002535993,0.000005490763],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009146701,"about_ca_system_score_gemma":0.00005154383,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001229893,"about_ca_topic_score_gemma":0.0001475842,"domain_scores_codex":[0.9975538,0.00002888185,0.0004286846,0.0011293,0.0003780898,0.0004812468],"domain_scores_gemma":[0.9979677,0.0001261284,0.001039623,0.0005950585,0.0001163224,0.0001551901],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005102026,0.0001455616,0.009076967,0.00008251583,0.00002539368,0.00003450988,0.00005836078,0.00000230579,0.9806587,0.000001865233,0.001195357,0.008667442],"study_design_scores_gemma":[0.0002209821,0.00001455625,0.004387329,0.0001715603,0.00003316531,0.00002692771,0.0001281514,0.0002603944,0.9896398,0.00006884799,0.004755992,0.0002923276],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995961,0.000319223,0.00005296009,0.000240117,0.001885302,0.0001391592,0.00006902573,0.00008899159,0.001244215],"genre_scores_gemma":[0.9976071,0.00002740078,0.0001577832,0.00001527427,0.0002263977,0.00003052925,0.00003323896,0.00001902546,0.001883261],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008981065,"threshold_uncertainty_score":0.9994259,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02583006719506916,"score_gpt":0.2576213554532003,"score_spread":0.2317912882581311,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}