{"id":"W2749345044","doi":"10.1038/s41598-017-09490-w","title":"The epigenetic modifier Fam208a is required to maintain epiblast cell fitness","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Czech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences; Akademie Věd České Republiky; Grantová Agentura České Republiky; Ministerstvo Školství, Mládeže a Tělovýchovy; Univerzita Karlova v Praze","keywords":"Epiblast; Epigenetics; Biology; Computational biology; Computer science; Genetics; Embryonic stem cell; Gene; Gastrulation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001082646,0.0002501703,0.0002453868,0.0002643495,0.0001797457,0.0002238206,0.0002484423,0.0003360771,0.001298709],"category_scores_gemma":[0.0002480153,0.0001492059,0.0001775959,0.0001094286,0.0002170455,0.000151736,0.0003464699,0.0004048958,0.000471934],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002246814,"about_ca_system_score_gemma":0.0001904044,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004129522,"about_ca_topic_score_gemma":0.0004628917,"domain_scores_codex":[0.9998881,0.00001523249,0.00001438763,0.00002613313,0.00003517161,0.00002102357],"domain_scores_gemma":[0.9997723,0.00004165167,0.00007116188,0.00003575924,0.00002034615,0.00005877794],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002893932,0.000003361914,0.0001776338,0.000006074997,0.000001410817,0.00003681326,0.000002367374,0.00001821899,0.9992266,0.000036216,0.000007373256,0.0004549436],"study_design_scores_gemma":[0.000008851823,0.00006717349,0.006486341,0.00000305863,0.000009044039,0.0004035294,0.00001070252,0.0007991307,0.9907927,0.00005369253,0.001361592,0.000004004552],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943323,0.0007321293,0.003469539,0.00008146326,0.00002705432,0.00001315018,0.0003524612,0.0001290778,0.0008627788],"genre_scores_gemma":[0.9970273,0.0001879114,0.001428974,0.00001752896,0.000004642684,0.00001433745,0.0002294815,0.00002833706,0.001061414],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001298709,"threshold_uncertainty_score":0.004344583,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01698408446435255,"score_gpt":0.2811851602526178,"score_spread":0.2642010757882652,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}