{"id":"W2749499656","doi":"10.1080/15548627.2017.1339001","title":"ESRRA (estrogen-related receptor α) is a key coordinator of transcriptional and post-translational activation of autophagy to promote innate host defense","year":2017,"lang":"en","type":"article","venue":"Autophagy","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Autophagy; Biology; Cell biology; ATG5; Innate immune system; BECN1; Sirtuin 1; BAG3; Autophagosome; ATG16L1; Effector; Receptor; Downregulation and upregulation; Gene; Biochemistry; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002301929,0.000249894,0.0003400189,0.0002721245,0.0001852847,0.0003458344,0.0001320825,0.000195271,0.001503961],"category_scores_gemma":[0.0001588448,0.0001126642,0.0003366873,0.0002223928,0.0002748414,0.0001864482,0.0002544352,0.0004048515,0.0005412081],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001982676,"about_ca_system_score_gemma":0.0001890567,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001535942,"about_ca_topic_score_gemma":0.0002733391,"domain_scores_codex":[0.9998285,0.00003752382,0.00001933828,0.00004295281,0.00004540712,0.00002627065],"domain_scores_gemma":[0.9998692,0.00001721129,0.00005196016,0.00001514667,0.0000215058,0.00002491671],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002251209,0.00002977151,0.001800473,0.0001940904,0.00003019119,0.0003407979,0.00004123003,0.000158383,0.9819183,0.0007427004,0.0004703997,0.01404854],"study_design_scores_gemma":[0.00005126418,0.0005816108,0.02597096,0.0000475257,0.00008452091,0.003075832,0.0001277046,0.0008179327,0.9116459,0.0007675571,0.05680645,0.00002279686],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8747995,0.08820524,0.02241899,0.001106087,0.0004330818,0.00007327816,0.001928882,0.000562682,0.01047218],"genre_scores_gemma":[0.9753557,0.01222218,0.004161656,0.0002571016,0.000106705,0.0000231544,0.001034762,0.00002408549,0.006814712],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001503961,"threshold_uncertainty_score":0.005031288,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01407810496215887,"score_gpt":0.278473314803675,"score_spread":0.2643952098415161,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}