{"id":"W2749610744","doi":"10.1016/s2468-1253(17)30246-7","title":"Seladelpar (MBX-8025), a selective PPAR-δ agonist, in patients with primary biliary cholangitis with an inadequate response to ursodeoxycholic acid: a double-blind, randomised, placebo-controlled, phase 2, proof-of-concept study","year":2017,"lang":"en","type":"article","venue":"˜The œLancet. Gastroenterology & hepatology","topic":"Liver Diseases and Immunity","field":"Medicine","cited_by":186,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; Toronto General Hospital; University of Calgary","funders":"Medical Research Council; National Institute for Health and Care Research","keywords":"Ursodeoxycholic acid; Placebo; Medicine; Gastroenterology; Double blind; Agonist; Internal medicine; Chemistry; Pharmacology; Receptor; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001447724,0.0006315103,0.002571822,0.0004343447,0.0004971196,0.00006971425,0.001013646,0.0002288894,0.00003327071],"category_scores_gemma":[0.0001116818,0.0004137571,0.0001882129,0.0002539583,0.0009033167,0.000376316,0.0002970567,0.001063328,0.00000845768],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002543064,"about_ca_system_score_gemma":0.0004662075,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006688859,"about_ca_topic_score_gemma":0.002499765,"domain_scores_codex":[0.9942105,0.002180867,0.0008819125,0.0009893265,0.0004485905,0.00128885],"domain_scores_gemma":[0.9959643,0.0002452282,0.000823456,0.002132053,0.0004122152,0.0004227292],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5270047,0.00411806,0.4654508,0.00002679097,0.0007114219,0.0001953022,0.001599204,0.00001541541,0.00006937111,0.000001288458,0.0001159895,0.0006917046],"study_design_scores_gemma":[0.5230166,0.03187842,0.4433661,0.00007444926,0.0006979661,0.0001404045,0.0003024013,0.0001215223,0.0001404908,0.000008586249,0.00005733446,0.000195738],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876478,0.00009250916,0.0002650149,0.001799964,0.0001625836,0.009715746,0.0001212892,0.00006614392,0.0001289142],"genre_scores_gemma":[0.9953659,0.0000054013,0.0002306664,0.002080243,0.0001457979,0.00190684,0.0001234682,0.0000753037,0.000066361],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02776035,"threshold_uncertainty_score":0.9998314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02540933150554975,"score_gpt":0.3025885056575918,"score_spread":0.2771791741520421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}