{"id":"W2749610744","doi":"10.1016/s2468-1253(17)30246-7","title":"Seladelpar (MBX-8025), a selective PPAR-δ agonist, in patients with primary biliary cholangitis with an inadequate response to ursodeoxycholic acid: a double-blind, randomised, placebo-controlled, phase 2, proof-of-concept study","year":2017,"lang":"en","type":"article","venue":"˜The œLancet. Gastroenterology & hepatology","topic":"Liver Diseases and Immunity","field":"Medicine","cited_by":186,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; Toronto General Hospital; University of Calgary","funders":"Medical Research Council; National Institute for Health and Care Research","keywords":"Ursodeoxycholic acid; Placebo; Medicine; Gastroenterology; Double blind; Agonist; Internal medicine; Chemistry; Pharmacology; Receptor; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001794805,0.001610754,0.003205611,0.0003709401,0.0002747602,0.0008303924,0.000697764,0.001904986,0.005486027],"category_scores_gemma":[0.001245341,0.0008505263,0.001546339,0.00044093,0.001158198,0.001208412,0.0004020356,0.002393427,0.001025813],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004822304,"about_ca_system_score_gemma":0.0007640685,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004950133,"about_ca_topic_score_gemma":0.001103458,"domain_scores_codex":[0.9995378,0.0002159351,0.00004300298,0.0000696787,0.00004930801,0.00008422186],"domain_scores_gemma":[0.9994189,0.0001979194,0.0001288066,0.00004192615,0.00005128244,0.0001613175],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.94809,0.006805761,0.001234852,0.002084194,0.001664923,0.0001209661,0.00008213535,0.0002674387,0.0116749,0.0001046656,0.0007691915,0.0271011],"study_design_scores_gemma":[0.8749216,0.1192002,0.00327513,0.00005252475,0.0007989257,0.00009380656,0.00005048545,0.0001817883,0.000697839,0.00006500431,0.0006436483,0.00001907786],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851885,0.009973159,0.0005717419,0.0007574093,0.0004407966,0.001191791,0.0004551712,0.0001046935,0.001316778],"genre_scores_gemma":[0.985893,0.006570112,0.001240062,0.001402896,0.000419646,0.00138073,0.000751974,0.0000232076,0.002318356],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005486027,"threshold_uncertainty_score":0.01835263,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02540933150554975,"score_gpt":0.3025885056575918,"score_spread":0.2771791741520421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}