{"id":"W2749663845","doi":"10.1158/1078-0432.ccr-17-1034","title":"Impact of Therapy on Genomics and Transcriptomics in High-Risk Prostate Cancer Treated with Neoadjuvant Docetaxel and Androgen Deprivation Therapy","year":2017,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Cancer Institute","keywords":"Docetaxel; Prostate cancer; Androgen deprivation therapy; Medicine; Oncology; Internal medicine; Neoadjuvant therapy; Cancer; Transcriptome; Genomics; Biology; Gene; Genetics; Genome; Breast cancer; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00157793,0.0002177103,0.0006170355,0.0002205919,0.0002741332,0.00009301004,0.0001911264,0.0001713569,0.00005472118],"category_scores_gemma":[0.0001572984,0.0001274525,0.00009119051,0.0002061219,0.001068303,0.0001413404,0.00005414805,0.0008095796,0.000001209904],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003316157,"about_ca_system_score_gemma":0.0009456444,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01847598,"about_ca_topic_score_gemma":0.001250411,"domain_scores_codex":[0.997652,0.0002664313,0.000471703,0.0005971232,0.0004909164,0.0005218269],"domain_scores_gemma":[0.9981906,0.0003569869,0.000200371,0.0005932724,0.0003665153,0.0002921939],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02417871,0.0003570202,0.7273858,0.000034989,0.0003065224,0.00003334577,0.0004216585,0.00001363525,0.002565631,0.000009455208,0.00005497958,0.2446382],"study_design_scores_gemma":[0.02347139,0.006491448,0.9618946,0.0002533598,0.00002686657,0.000003342983,0.0000415619,0.0002366035,0.006844339,0.0001987719,0.000401564,0.0001361419],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863543,0.00985999,0.000001096432,0.001656163,0.00003489784,0.001816754,0.0001841167,0.00001233069,0.00008035427],"genre_scores_gemma":[0.7285373,0.2708987,0.00003527808,0.00003448812,0.00008886558,0.0001995209,0.00001551798,0.00003241298,0.0001578401],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2610388,"threshold_uncertainty_score":0.9880601,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1769528891299503,"score_gpt":0.5022077878579497,"score_spread":0.3252548987279995,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}