{"id":"W2749663845","doi":"10.1158/1078-0432.ccr-17-1034","title":"Impact of Therapy on Genomics and Transcriptomics in High-Risk Prostate Cancer Treated with Neoadjuvant Docetaxel and Androgen Deprivation Therapy","year":2017,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Cancer Institute","keywords":"Docetaxel; Prostate cancer; Androgen deprivation therapy; Medicine; Oncology; Internal medicine; Neoadjuvant therapy; Cancer; Transcriptome; Genomics; Biology; Gene; Genetics; Genome; Breast cancer; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001745508,0.0001182456,0.0002586138,0.0001997783,0.0001387504,0.0003760628,0.0000931549,0.0001505647,0.0006716868],"category_scores_gemma":[0.0003470408,0.0000630615,0.0001174451,0.0002630672,0.0001512797,0.000106363,0.0001100729,0.0001981674,0.00008835017],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004431014,"about_ca_system_score_gemma":0.0003454274,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001107792,"about_ca_topic_score_gemma":0.00214005,"domain_scores_codex":[0.9998735,0.00003419449,0.000006674871,0.00002905538,0.00003246491,0.00002410775],"domain_scores_gemma":[0.9998722,0.00003237731,0.00004306885,0.000006234616,0.00001705606,0.00002913764],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01158745,0.0006310819,0.6925454,0.0001914323,0.0002268465,0.0008400943,0.0002622422,0.001765636,0.2296709,0.0001926239,0.001176327,0.06090997],"study_design_scores_gemma":[0.00006443826,0.001340482,0.9816139,0.00001325047,0.00008099298,0.0006921915,0.0001836512,0.001482025,0.01335225,0.0001245291,0.001045327,0.000007060201],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985135,0.0005522679,0.0001601112,0.00008224457,0.000004164318,0.00001219334,0.0002379651,0.00000726807,0.0004303301],"genre_scores_gemma":[0.9991847,0.0001319704,0.0001672391,0.00007347485,0.000003846511,0.00001470826,0.0002622235,0.000001944406,0.0001597905],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001107792,"threshold_uncertainty_score":0.003214955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1769528891299503,"score_gpt":0.5022077878579497,"score_spread":0.3252548987279995,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}