{"id":"W2749697150","doi":"10.1016/j.celrep.2017.07.077","title":"Improving the Immunogenicity of Native-like HIV-1 Envelope Trimers by Hyperstabilization","year":2017,"lang":"en","type":"article","venue":"Cell Reports","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":176,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"H2020 European Research Council; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; National Institutes of Health; International AIDS Vaccine Initiative","keywords":"Antigenicity; Gp41; Immunogenicity; Trimer; Chemistry; Glycoprotein; Glycobiology; Cell biology; Epitope; Biophysics; Biochemistry; Antibody; Biology; Glycan; Immunology; Dimer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001703735,0.0002587215,0.00009550604,0.0001201746,0.00007949156,0.000179406,0.0001787165,0.0001371174,0.0006090562],"category_scores_gemma":[0.0001428671,0.00009679126,0.0001756739,0.00007113571,0.0001185293,0.0001841234,0.0001809901,0.0003763674,0.0001699602],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002390829,"about_ca_system_score_gemma":0.0001005727,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004085898,"about_ca_topic_score_gemma":0.0005587685,"domain_scores_codex":[0.9999074,0.00002105861,0.000007997208,0.00001161981,0.00003118601,0.00002071716],"domain_scores_gemma":[0.9999478,0.000008260543,0.00001840295,0.00000862556,0.000008043924,0.000008993119],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004848879,0.0000175554,0.0002509931,0.00001146372,0.000004393293,0.0000148067,0.00001198038,0.0002349778,0.9975289,0.00009007487,0.00002492473,0.00176152],"study_design_scores_gemma":[0.0000135563,0.0003919253,0.003078543,0.000003624994,0.00001716609,0.0002318196,0.00001818694,0.002013003,0.9927468,0.00005549135,0.001425507,0.000004450123],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969257,0.0002340195,0.002169176,0.00003287887,0.000006910775,0.00001513969,0.00004414882,0.00002636475,0.000545729],"genre_scores_gemma":[0.9965935,0.0001910149,0.002474776,0.00003582826,0.000004447435,0.000007673975,0.0001358563,0.00001095735,0.0005459858],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006090562,"threshold_uncertainty_score":0.002037525,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01548247968330687,"score_gpt":0.248200954270719,"score_spread":0.2327184745874121,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}