{"id":"W2749697150","doi":"10.1016/j.celrep.2017.07.077","title":"Improving the Immunogenicity of Native-like HIV-1 Envelope Trimers by Hyperstabilization","year":2017,"lang":"en","type":"article","venue":"Cell Reports","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":176,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"H2020 European Research Council; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; National Institutes of Health; International AIDS Vaccine Initiative","keywords":"Antigenicity; Gp41; Immunogenicity; Trimer; Chemistry; Glycoprotein; Glycobiology; Cell biology; Epitope; Biophysics; Biochemistry; Antibody; Biology; Glycan; Immunology; Dimer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000367344,0.0001051747,0.0001631177,0.00002749122,0.0005644913,0.00002332461,0.0002040129,0.00009385586,0.0002718513],"category_scores_gemma":[0.0002452202,0.00006897291,0.00008127342,0.00003232199,0.0003767451,0.00008332348,0.0001211454,0.0001391015,0.00009969555],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000487313,"about_ca_system_score_gemma":0.000143396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005880784,"about_ca_topic_score_gemma":0.00001299826,"domain_scores_codex":[0.9991331,0.0000955971,0.0002598829,0.000227356,0.00005367371,0.0002303693],"domain_scores_gemma":[0.998709,0.00007491678,0.0004058888,0.0006994092,0.00009103423,0.00001981707],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007705212,0.0001801601,0.02586062,0.00001955649,0.0001406697,0.00004430971,0.000463809,0.000001402036,0.9571706,0.00001106224,0.008931871,0.00709887],"study_design_scores_gemma":[0.0007707122,0.0001077257,0.0124978,0.000008626772,0.00004374654,0.00007021587,0.0002762305,0.000001916274,0.9342796,0.00002438884,0.0518146,0.0001044936],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9831327,0.003959144,0.0002125293,0.0001334703,0.0004335975,0.0003982881,0.00004554672,0.00002036002,0.01166437],"genre_scores_gemma":[0.9893079,0.000113614,0.00002606316,0.00001272366,0.000006952571,0.0000198981,0.0001781182,0.000009283844,0.01032548],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04288273,"threshold_uncertainty_score":0.4341668,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01548247968330687,"score_gpt":0.248200954270719,"score_spread":0.2327184745874121,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}