{"id":"W2749707246","doi":"10.1128/aac.00958-17","title":"No Clinically Relevant Drug-Drug Interactions between Methadone or Buprenorphine-Naloxone and Antiviral Combination Glecaprevir and Pibrentasvir","year":2017,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vale (Canada)","funders":"AbbVie","keywords":"Buprenorphine; Drug; Methadone; (+)-Naloxone; Medicine; Pharmacology; Opioid; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007670544,0.0003098052,0.0004582772,0.00009526734,0.001239133,0.0002131525,0.0002195935,0.0002109253,0.0002295186],"category_scores_gemma":[0.00007943415,0.0002694148,0.00007986857,0.00006541218,0.000434051,0.0005031018,0.0001657896,0.0007586875,0.00003829253],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002778363,"about_ca_system_score_gemma":0.00003298787,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000306814,"about_ca_topic_score_gemma":0.000111398,"domain_scores_codex":[0.9982624,0.0003013057,0.0004834638,0.0005057777,0.0001065279,0.0003405066],"domain_scores_gemma":[0.9988131,0.0002556995,0.0004021482,0.0002611252,0.00008601319,0.0001819489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002037598,0.001140875,0.4558028,0.0003745904,0.0008690913,0.00003292019,0.002497986,0.000001130697,0.1467267,0.0001778629,0.02435189,0.3659865],"study_design_scores_gemma":[0.01414345,0.0005177992,0.4328466,0.0003212707,0.0004954723,0.00009577755,0.0001069319,0.001320539,0.1050103,0.0009792,0.4429683,0.001194412],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899697,0.00005225547,0.0001151286,0.007019986,0.0008327204,0.0006263047,0.0001055548,0.00006410788,0.001214198],"genre_scores_gemma":[0.984246,0.007149912,0.0004717826,0.004240484,0.0004149111,0.00001753458,0.00004619235,0.00003522916,0.003378016],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4186164,"threshold_uncertainty_score":0.9999758,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1066724011781819,"score_gpt":0.4269629703697123,"score_spread":0.3202905691915304,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}