{"id":"W2749707246","doi":"10.1128/aac.00958-17","title":"No Clinically Relevant Drug-Drug Interactions between Methadone or Buprenorphine-Naloxone and Antiviral Combination Glecaprevir and Pibrentasvir","year":2017,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vale (Canada)","funders":"AbbVie","keywords":"Buprenorphine; Drug; Methadone; (+)-Naloxone; Medicine; Pharmacology; Opioid; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001515293,0.0004877969,0.001214806,0.0001382363,0.0002363421,0.000326237,0.0003441791,0.0006121441,0.003233188],"category_scores_gemma":[0.003337932,0.0002649695,0.0005961049,0.0001568573,0.0004257374,0.0004659531,0.0002205416,0.0009190644,0.0002923688],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005015951,"about_ca_system_score_gemma":0.0007260249,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005016214,"about_ca_topic_score_gemma":0.002243152,"domain_scores_codex":[0.9983283,0.0009150063,0.0001286514,0.0002018818,0.0003213212,0.0001048138],"domain_scores_gemma":[0.9978542,0.0009121459,0.0005505827,0.0002022745,0.0001492041,0.0003316196],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.4268216,0.02874564,0.1202697,0.002201441,0.00478123,0.00295557,0.0006363041,0.00255067,0.2270314,0.001098551,0.003219253,0.1796888],"study_design_scores_gemma":[0.03786637,0.5044316,0.3697606,0.0001240532,0.002241675,0.003287889,0.0002177265,0.006662549,0.05150205,0.0007184849,0.02310496,0.0000821661],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993417,0.00139048,0.0008877559,0.0001170575,0.00007064058,0.001356293,0.0006887661,0.00003812042,0.002033815],"genre_scores_gemma":[0.9968846,0.000260977,0.0007236816,0.0001195612,0.00003615962,0.0002589764,0.000420033,0.000006190525,0.001289847],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003233188,"threshold_uncertainty_score":0.0108161,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1066724011781819,"score_gpt":0.4269629703697123,"score_spread":0.3202905691915304,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}