{"id":"W2749710160","doi":"10.1016/j.biomaterials.2017.08.019","title":"The role of insulin growth factor-1 on the vascular regenerative effect of MAA coated disks and macrophage-endothelial cell crosstalk","year":2017,"lang":"en","type":"article","venue":"Biomaterials","topic":"Connective tissue disorders research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Government of Shandong Province; Department of Family and Community Medicine, University of Toronto; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of Toronto; Canada Excellence Research Chairs, Government of Canada; Ontario Neurotrauma Foundation; Orthopaedic Research Foundation","keywords":"Macrophage polarization; Cell biology; M2 Macrophage; Growth factor; Crosstalk; Vascular endothelial growth factor; Angiogenesis; Macrophage; Chemistry; In vitro; Biology; Cancer research; Biochemistry; Receptor; VEGF receptors","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004583597,0.0001483189,0.0002101128,0.00001858345,0.0003453999,0.000102053,0.0003857554,0.00009803879,0.00003412609],"category_scores_gemma":[0.0006481615,0.00007990989,0.00007771804,0.00002462572,0.0005136903,0.000003919064,0.0002521504,0.00001772618,0.000004592999],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005913793,"about_ca_system_score_gemma":0.00002778518,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003148334,"about_ca_topic_score_gemma":0.00003030909,"domain_scores_codex":[0.9988413,0.000403691,0.0001874429,0.0002320763,0.0001530829,0.0001823851],"domain_scores_gemma":[0.9989338,0.0001288252,0.0002028745,0.000590308,0.0001094533,0.00003477648],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005713851,0.00002834194,0.00178892,0.00003522851,0.0000839816,9.211726e-7,0.00009659227,1.61044e-7,0.9960626,0.0001474897,0.00003472659,0.001149624],"study_design_scores_gemma":[0.0007934934,0.0006341253,0.009131406,0.00001224431,0.00001212385,7.590231e-7,0.00004443631,0.000004719113,0.9879209,0.00009056225,0.001270357,0.00008482732],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967985,0.001843712,0.000004129228,0.00006994483,0.00009105833,0.0004885646,0.0003413286,0.000003130465,0.0003596105],"genre_scores_gemma":[0.9993148,0.0004278632,0.000005181582,0.000005465748,0.00006036428,0.00003918747,0.00002277966,0.00001811058,0.0001062242],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008141683,"threshold_uncertainty_score":0.3258631,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01032752051977309,"score_gpt":0.2799282405496778,"score_spread":0.2696007200299047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}