{"id":"W2749901817","doi":"10.1186/s13054-017-1798-7","title":"Selepressin, a novel selective vasopressin V1A agonist, is an effective substitute for norepinephrine in a phase IIa randomized, placebo-controlled trial in septic shock patients","year":2017,"lang":"en","type":"article","venue":"Critical Care","topic":"Sepsis Diagnosis and Treatment","field":"Medicine","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; St. Paul's Hospital","funders":"Ferring; B. Braun Melsungen","keywords":"Medicine; Vasopressin; Septic shock; Norepinephrine; Agonist; Placebo; Anesthesia; Randomized controlled trial; Shock (circulatory); Terlipressin; Intensive care medicine; Internal medicine; Sepsis; Dopamine; Receptor; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002420125,0.001045132,0.001698296,0.0003351951,0.000311564,0.001032893,0.0005059668,0.001332644,0.003796363],"category_scores_gemma":[0.00167546,0.0004595444,0.00120216,0.0003261975,0.0008889959,0.0006717111,0.0002353603,0.001905403,0.0005575096],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003990753,"about_ca_system_score_gemma":0.000791708,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002493048,"about_ca_topic_score_gemma":0.0007172033,"domain_scores_codex":[0.9993502,0.0003952167,0.00006092381,0.00009223034,0.00003718413,0.00006427673],"domain_scores_gemma":[0.9989769,0.000296402,0.0003036599,0.00007109287,0.00006802172,0.0002838748],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9792559,0.003780848,0.0005310553,0.000456665,0.0005301639,0.00003049494,0.00003425161,0.0001690154,0.006321182,0.00007386623,0.0002793164,0.008537157],"study_design_scores_gemma":[0.9198376,0.07725842,0.001268529,0.00003572137,0.0002539312,0.0000263571,0.00001662962,0.0001942701,0.0007021546,0.00005085122,0.0003481087,0.000007480746],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893185,0.005006299,0.000729439,0.000621395,0.0004729443,0.002160928,0.0004942129,0.00006316547,0.001133051],"genre_scores_gemma":[0.9891478,0.00318835,0.00132266,0.0008740818,0.0004238162,0.002748796,0.0006726787,0.00001584024,0.00160602],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003796363,"threshold_uncertainty_score":0.01279902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06276698193781746,"score_gpt":0.4129050423404751,"score_spread":0.3501380604026577,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}