{"id":"W2749901817","doi":"10.1186/s13054-017-1798-7","title":"Selepressin, a novel selective vasopressin V1A agonist, is an effective substitute for norepinephrine in a phase IIa randomized, placebo-controlled trial in septic shock patients","year":2017,"lang":"en","type":"article","venue":"Critical Care","topic":"Sepsis Diagnosis and Treatment","field":"Medicine","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; St. Paul's Hospital","funders":"Ferring; B. Braun Melsungen","keywords":"Medicine; Vasopressin; Septic shock; Norepinephrine; Agonist; Placebo; Anesthesia; Randomized controlled trial; Shock (circulatory); Terlipressin; Intensive care medicine; Internal medicine; Sepsis; Dopamine; Receptor; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004639119,0.0004053752,0.001931719,0.0002011158,0.0002723908,0.0001536214,0.0001856567,0.000230591,0.0000585992],"category_scores_gemma":[0.007697647,0.0003124611,0.0004954862,0.0001052956,0.0003085232,0.0002727963,0.0000668833,0.0002938804,0.000007445959],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004186278,"about_ca_system_score_gemma":0.0001703081,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003094222,"about_ca_topic_score_gemma":0.0003169324,"domain_scores_codex":[0.9973875,0.0002353119,0.0006820108,0.0007690972,0.0003562025,0.0005699114],"domain_scores_gemma":[0.9964309,0.001934504,0.0001547864,0.0006145796,0.0005672357,0.0002980395],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9759988,0.006139917,0.009863325,0.0002446334,0.0002900794,0.0001002497,0.001862323,0.000006573859,0.0001055704,0.0003296832,0.0001348446,0.004924018],"study_design_scores_gemma":[0.9690691,0.00297173,0.02051322,0.0004207519,0.001178702,0.000004764492,0.0001731837,0.002195518,0.002906031,0.0002202003,0.00004983883,0.0002969755],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9821763,0.0005346569,0.000251682,0.000615937,0.0003694781,0.0148639,0.000200684,0.00003824952,0.0009490903],"genre_scores_gemma":[0.9873067,0.00001104836,0.0006069401,0.0004020345,0.0002782226,0.01112433,0.000192429,0.00004686143,0.00003148275],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01064989,"threshold_uncertainty_score":0.9999328,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06276698193781746,"score_gpt":0.4129050423404751,"score_spread":0.3501380604026577,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}