{"id":"W2749902186","doi":"10.1016/j.exphem.2017.08.001","title":"Tet2 restrains inflammatory gene expression in macrophages","year":2017,"lang":"en","type":"article","venue":"Experimental Hematology","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":290,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sunnybrook Health Science Centre; Health Sciences Centre; Queen's University","funders":"Southeastern Ontario Academic Medical Organization; Queen's University; Ontario Institute for Cancer Research; Canada Foundation for Innovation; Canadian Institutes of Health Research; European Hematology Association","keywords":"Biology; Epigenetics; Haematopoiesis; Myeloid; Molecular biology; Inflammation; Gene expression; Cancer research; Gene; Stem cell; Immunology; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000163843,0.0001797277,0.0003933098,0.0001600641,0.0002277393,0.00003107514,0.000342343,0.000204565,0.0006346502],"category_scores_gemma":[0.0001345493,0.0001593124,0.00006904908,0.00004076368,0.0004144762,0.0001526669,0.0003764637,0.0003001608,0.0002040185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002639931,"about_ca_system_score_gemma":0.0001505305,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004744725,"about_ca_topic_score_gemma":0.00001310993,"domain_scores_codex":[0.9985621,0.0000694409,0.0002984791,0.0003823317,0.000228718,0.0004589424],"domain_scores_gemma":[0.9987695,0.0000444322,0.0001090027,0.0008657836,0.0000267948,0.000184534],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003939051,0.0002553491,0.05595963,0.00005438638,0.00001773121,0.003852434,0.0005985358,3.807032e-7,0.9336675,0.002486459,0.002341298,0.0003724262],"study_design_scores_gemma":[0.002825522,0.0001516411,0.02795308,0.00009652865,0.000003390546,0.0009815714,0.0005217362,0.00004654372,0.9661645,0.00008131987,0.001042221,0.0001318835],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9835104,0.003053341,0.00001514228,0.0008233397,0.0002166574,0.0004235956,0.000003627428,0.00005678113,0.01189715],"genre_scores_gemma":[0.9956834,0.00005397538,0.002733112,0.0001461789,0.0001152861,0.0001046342,0.00001386552,0.00003541882,0.00111417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03249709,"threshold_uncertainty_score":0.6948975,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02830469098849471,"score_gpt":0.3625325449675375,"score_spread":0.3342278539790428,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}