{"id":"W2750131287","doi":"10.1161/circulationaha.117.029435","title":"The Low-Density Lipoprotein Receptor Genotype Is a Significant Determinant of the Rebound in Low-Density Lipoprotein Cholesterol Concentration After Lipoprotein Apheresis Among Patients With Homozygous Familial Hypercholesterolemia","year":2017,"lang":"en","type":"letter","venue":"Circulation","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Medicine; Familial hypercholesterolemia; Lipoprotein; Genotype; LDL receptor; Internal medicine; Low-density lipoprotein; Apheresis; Cholesterol; Endocrinology; Genetics; Gene; Platelet; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006431009,0.0003813622,0.0007114727,0.0003843115,0.0008320838,0.000690785,0.0004451717,0.003899406,0.00170614],"category_scores_gemma":[0.003064082,0.0001610371,0.0002921105,0.0004687351,0.0007982605,0.0003847189,0.0001663692,0.00300552,0.001294602],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001183992,"about_ca_system_score_gemma":0.0005161343,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001267863,"about_ca_topic_score_gemma":0.00201873,"domain_scores_codex":[0.9992357,0.0002920922,0.00007224552,0.0001183262,0.0001517124,0.0001298107],"domain_scores_gemma":[0.9984033,0.0008976733,0.0001964762,0.00005645783,0.0002273446,0.0002187511],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003273062,0.0008839717,0.4388254,0.0005306479,0.0001730053,0.2093233,0.0008245901,0.0002923601,0.007500549,0.003733115,0.1972164,0.1374237],"study_design_scores_gemma":[0.0007143455,0.002085784,0.4194012,0.001082872,0.0004587214,0.4128239,0.001594266,0.005751623,0.004295649,0.01565842,0.1359726,0.0001605928],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.3922845,0.02573282,0.001453168,0.5388092,0.006903043,0.0001331627,0.0002803491,0.0001653629,0.03423829],"genre_scores_gemma":[0.8435657,0.008270389,0.001033501,0.1055842,0.03239003,0.0001020308,0.0001772757,0.00003301208,0.008843949],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.003899406,"threshold_uncertainty_score":0.00859046,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007979396848447137,"score_gpt":0.2114472151900231,"score_spread":0.203467818341576,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}