{"id":"W2750250735","doi":"10.3389/fimmu.2017.00985","title":"Reactivation of Intestinal Inflammation Is Suppressed by Catestatin in a Murine Model of Colitis via M1 Macrophages and Not the Gut Microbiota","year":2017,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Polysaccharides and Plant Cell Walls","field":"Agricultural and Biological Sciences","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital Research Institute of Manitoba; University of Manitoba","funders":"Canadian Institutes of Health Research; Crohn's and Colitis Canada; Mitacs; Research Manitoba; Health Sciences Centre Foundation","keywords":"Colitis; Inflammatory bowel disease; Lipopolysaccharide; Inflammation; Macrophage; Immunology; Tumor necrosis factor alpha; Gut flora; Cytokine; Interleukin; Proinflammatory cytokine; Interleukin 10; Medicine; In vitro; Internal medicine; Biology; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001564176,0.00007376864,0.0001737939,0.00002148172,0.00006368692,0.00001509952,0.0002380325,0.00008016694,0.0000172561],"category_scores_gemma":[0.00007869945,0.00003297069,0.00001826742,0.00005094935,0.0001909179,0.00009566826,0.00007252035,0.0001030038,3.6774e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001192236,"about_ca_system_score_gemma":0.000006798815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00484472,"about_ca_topic_score_gemma":0.0005492937,"domain_scores_codex":[0.9994116,0.00005155979,0.0002329231,0.0001260552,0.00004430383,0.0001335961],"domain_scores_gemma":[0.9995305,0.00009965769,0.0002528089,0.00007744295,0.00002962579,0.00000999487],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001327147,0.00001875347,0.02083084,0.000009347247,0.000008037519,8.251444e-7,0.0002733361,0.000007864183,0.9600702,0.00002531655,0.0003770641,0.01824574],"study_design_scores_gemma":[0.000297358,0.00009612259,0.5278994,0.00004425121,0.000005225597,0.000005498081,0.0001696683,0.004715206,0.4654412,0.001067421,0.0001806984,0.00007799003],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981785,0.0002302107,0.00006185361,0.001136138,0.00007001301,0.0001377762,0.0001241069,0.000003113677,0.00005826205],"genre_scores_gemma":[0.9989846,0.0003409438,0.0004737475,0.00002781151,0.000008292766,0.000007099137,0.00004141656,6.422002e-7,0.0001153844],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5070685,"threshold_uncertainty_score":0.7323799,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01092985257313964,"score_gpt":0.200584580501491,"score_spread":0.1896547279283514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}