{"id":"W2750336610","doi":"10.1016/j.ejphar.2017.08.011","title":"Attenuation of Sunitinib-induced cardiotoxicity through the A3 adenosine receptor activation","year":2017,"lang":"en","type":"article","venue":"European Journal of Pharmacology","topic":"Synthesis of Tetrazole Derivatives","field":"Chemistry","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Faculty of Health Sciences, Queen's University; National Centre for Biological Sciences; Indo-French Centre for Applied Mathematics; Coventry University; University of Missouri","keywords":"Sunitinib; Cardiotoxicity; Medicine; Tyrosine-kinase inhibitor; Pharmacology; HL60; Cancer research; Cancer; Internal medicine; Chemotherapy; Leukemia","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0008752628,0.0001424466,0.0002923268,0.00004848306,0.0002796096,0.00003478548,0.0008579885,0.00004097227,0.0009895512],"category_scores_gemma":[0.0008758847,0.000106667,0.0001599438,0.00004363693,0.0002241957,0.0004136531,0.0001194911,0.0004241909,0.00002318721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005447825,"about_ca_system_score_gemma":0.0000565378,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006347586,"about_ca_topic_score_gemma":3.227083e-7,"domain_scores_codex":[0.9984156,0.0004615973,0.0005538754,0.0001275372,0.0002704265,0.0001709048],"domain_scores_gemma":[0.9970656,0.000364273,0.001875597,0.0002963977,0.0003527627,0.00004535666],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001893944,0.00008028294,0.0005027906,0.00002494728,0.0002446827,0.00001718425,0.0007596955,0.00002646314,0.9812977,0.00002920993,0.007332659,0.009494948],"study_design_scores_gemma":[0.001090674,0.00008249591,0.01525843,0.00007202564,0.00009539452,0.00002842433,0.0003332309,0.00001049144,0.9679117,0.00002314617,0.01499673,0.00009723144],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9765968,0.00007301811,0.0002761669,0.004911122,0.0005762218,0.00006059176,0.000009430152,0.00001242704,0.0174842],"genre_scores_gemma":[0.9977165,0.00007829118,0.0004508735,0.0002235921,0.001392851,0.000001358209,0.000002401749,0.00003038875,0.0001037787],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02111964,"threshold_uncertainty_score":0.9999237,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06071248158862594,"score_gpt":0.3288492266862604,"score_spread":0.2681367450976345,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}