{"id":"W2750529480","doi":"10.1186/s12862-017-1035-7","title":"Evaluating the maintenance of disease-associated variation at the blood group-related gene B4galnt2 in house mice","year":2017,"lang":"en","type":"article","venue":"BMC Evolutionary Biology","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Exzellenzclusters Entzündungsforschung; Max-Planck-Gesellschaft; Deutsche Forschungsgemeinschaft; International Max Planck Research School for Environmental, Cellular and Molecular Microbiology","keywords":"Biology; Allele; Balancing selection; Genetics; House mice; Heterozygote advantage; Haplotype; Gastrointestinal tract; Gene; Phenotype; Natural selection; Immunology; Selection (genetic algorithm); Zoology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005281658,0.0001184424,0.0002234784,0.00003976834,0.0004112899,0.000005242136,0.0001888293,0.0001180555,0.00004933896],"category_scores_gemma":[0.001273878,0.00006643174,0.00008971401,0.00008963553,0.0002670031,0.00004798917,0.0001134675,0.0001242756,0.00002469907],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001486627,"about_ca_system_score_gemma":0.0001484393,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007146376,"about_ca_topic_score_gemma":0.0005557216,"domain_scores_codex":[0.9988291,0.0002790153,0.0002890694,0.000242507,0.0001249161,0.0002354449],"domain_scores_gemma":[0.9987827,0.0002862679,0.0003462136,0.0004545109,0.00008084028,0.00004946853],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007789961,0.0006174413,0.9826441,0.00001727728,0.0002488324,0.00003311133,0.0001733219,0.0001727096,0.01340512,0.001362238,0.0002520246,0.0002948298],"study_design_scores_gemma":[0.003564209,0.0003077297,0.9864905,0.00004171232,0.0002229941,0.00004377592,0.00002058853,0.005445848,0.00003597209,0.003714398,0.00004409518,0.00006818213],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952677,0.001879798,0.00004072263,0.001839531,0.0001451657,0.0005283688,0.0000704833,0.00002813731,0.000200072],"genre_scores_gemma":[0.99852,0.0001565628,0.0002538509,0.0001306161,0.00002579905,0.00005922727,0.0001847841,0.0000139467,0.0006552121],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01336914,"threshold_uncertainty_score":0.3163351,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03708165868530222,"score_gpt":0.3171159497826725,"score_spread":0.2800342910973703,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}