{"id":"W2750589052","doi":"10.1016/j.str.2017.07.017","title":"Comprehensive Analysis of the Human SH3 Domain Family Reveals a Wide Variety of Non-canonical Specificities","year":2017,"lang":"en","type":"article","venue":"Structure","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":147,"is_retracted":false,"has_abstract":false,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Eshelman Institute for Innovation, University of North Carolina at Chapel Hill; Biological and Environmental Research; Janssen Biotech; Canadian Institutes of Health Research; Wellcome; Innovative Medicines Initiative; Ontario Ministry of Research, Innovation and Science; Novartis Pharma; Canada Foundation for Innovation; Wellcome Trust; Fundação de Amparo à Pesquisa do Estado de São Paulo; Genome Canada; AbbVie; Merck; Pfizer; Boehringer Ingelheim","keywords":"SH3 domain; Computational biology; Biology; Plasma protein binding; Binding site; Peptide; Genetics; Binding selectivity; Signal transduction; Cell biology; Biochemistry; Proto-oncogene tyrosine-protein kinase Src","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009576933,0.0002665686,0.0001903097,0.0002580657,0.0001961061,0.0001910968,0.0001464092,0.0001422007,0.0007577578],"category_scores_gemma":[0.00008230802,0.00008863827,0.0002057173,0.0002425018,0.0001397933,0.0001417917,0.0001768028,0.0002803716,0.0002908142],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002322495,"about_ca_system_score_gemma":0.0002781718,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001399415,"about_ca_topic_score_gemma":0.003434347,"domain_scores_codex":[0.9999609,0.000003690419,0.000002997921,0.000008668008,0.00001460799,0.000009114637],"domain_scores_gemma":[0.999947,0.00001335269,0.000009591807,0.000008090971,0.000009082309,0.00001298574],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002837502,0.00001573705,0.003108087,0.00006245577,0.00002375444,0.0002406896,0.00003148192,0.000312878,0.9885318,0.0003070149,0.0002179002,0.006864397],"study_design_scores_gemma":[0.00003047374,0.0001478254,0.1643974,0.00001876234,0.0001571551,0.004272967,0.000135462,0.004619685,0.8084176,0.001327434,0.01645023,0.000025034],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992557,0.002025139,0.003162718,0.00008914319,0.000007174332,0.000007042898,0.001108741,0.0000503489,0.0009926596],"genre_scores_gemma":[0.9916534,0.001149556,0.00296081,0.00006074748,0.000008062171,0.00001100112,0.002880845,0.00002009404,0.001255526],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001399415,"threshold_uncertainty_score":0.002782524,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01491790509402947,"score_gpt":0.2764641469420788,"score_spread":0.2615462418480494,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}