{"id":"W2750666977","doi":"10.1021/jacs.7b06176","title":"Tryptorubin A: A Polycyclic Peptide from a Fungus-Derived Streptomycete","year":2017,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Complementary and Integrative Health; Fogarty International Center; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Harvard Medical School; National Institute of General Medical Sciences; Merck","keywords":"Fungus; Streptomyces; Bacteria; Symbiosis; Chemistry; Genome; Strain (injury); Actinomycetales; Gene; Peptide; Stereochemistry; Microbiology; Cyclic peptide; Botany; Biology; Biochemistry; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005322323,0.0002826414,0.0001217801,0.0002333095,0.0001203315,0.0002833771,0.0001403543,0.0002040972,0.0006433072],"category_scores_gemma":[0.00007350717,0.00007127512,0.0001300338,0.000300163,0.00009100229,0.0001335817,0.0001174171,0.0002228692,0.0002809158],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001530564,"about_ca_system_score_gemma":0.0001575812,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009408309,"about_ca_topic_score_gemma":0.0007627917,"domain_scores_codex":[0.9999446,0.000007944152,0.000004896878,0.00001836798,0.000013091,0.00001109492],"domain_scores_gemma":[0.9999516,0.000008093742,0.00001255876,0.000004777016,0.000006098486,0.0000168815],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001141862,0.000007492002,0.0002923567,0.00001220791,0.000001889303,0.0001117953,0.000006972453,0.00005162678,0.9984767,0.00002150557,0.00001274697,0.0008905513],"study_design_scores_gemma":[0.00001555368,0.000243564,0.01302538,0.000004809996,0.00001196034,0.0007428661,0.00005399328,0.001426869,0.9825264,0.00004772248,0.001893241,0.000007610638],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952923,0.0002703261,0.002144597,0.00002897941,0.000009062898,0.00001668069,0.0009488788,0.00003472048,0.001254509],"genre_scores_gemma":[0.98727,0.0004455658,0.006522752,0.00002715844,0.000007237097,0.00001249899,0.003364484,0.00002898432,0.002321391],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009408309,"threshold_uncertainty_score":0.002152085,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01382803129996876,"score_gpt":0.2646013590568473,"score_spread":0.2507733277568786,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}