{"id":"W2750666977","doi":"10.1021/jacs.7b06176","title":"Tryptorubin A: A Polycyclic Peptide from a Fungus-Derived Streptomycete","year":2017,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Complementary and Integrative Health; Fogarty International Center; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Harvard Medical School; National Institute of General Medical Sciences; Merck","keywords":"Fungus; Streptomyces; Bacteria; Symbiosis; Chemistry; Genome; Strain (injury); Actinomycetales; Gene; Peptide; Stereochemistry; Microbiology; Cyclic peptide; Botany; Biology; Biochemistry; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001715347,0.0001624462,0.000544506,0.00001068691,0.000216077,0.0000642068,0.0006087521,0.00006958329,0.00008275773],"category_scores_gemma":[0.0006428058,0.00008756592,0.000919293,0.00008714968,0.0006336354,0.00009286344,0.0001976552,0.0006245378,0.000007661727],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001350589,"about_ca_system_score_gemma":0.0001056495,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002593265,"about_ca_topic_score_gemma":0.000001551962,"domain_scores_codex":[0.9988403,0.00003296088,0.0003585841,0.0001868531,0.00033882,0.0002425132],"domain_scores_gemma":[0.9978033,0.00008497068,0.00123956,0.0006076985,0.00009499118,0.0001694735],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002376705,0.00007581398,0.004450024,0.00000704119,0.0002877281,0.000007236809,0.0001442385,6.289687e-8,0.9606038,7.289446e-7,0.02779627,0.006389436],"study_design_scores_gemma":[0.0008247044,0.00009491985,0.0559282,0.0001407819,0.000264021,0.00009034911,0.000239358,0.00001185187,0.9328734,0.0000759805,0.009329296,0.0001271588],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9753092,0.0002479131,0.000005455657,0.0239343,0.0002190433,0.00008856777,0.00001389814,0.00001081202,0.0001707896],"genre_scores_gemma":[0.9916643,0.0002013044,0.003977646,0.00241749,0.001409436,2.079846e-7,0.000001168689,0.00001807458,0.0003104088],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05147817,"threshold_uncertainty_score":0.3570835,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01382803129996876,"score_gpt":0.2646013590568473,"score_spread":0.2507733277568786,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}