{"id":"W2750791344","doi":"10.1016/j.bbabio.2017.08.012","title":"Mitochondrial transition ROS spike (mTRS) results from coordinated activities of complex I and nicotinamide nucleotide transhydrogenase","year":2017,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Bioenergetics","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Prince Edward Island","funders":"Natural Sciences and Engineering Research Council of Canada; Ministry of Higher Education","keywords":"Mitochondrion; Oxidative stress; Mitochondrial ROS; Reactive oxygen species; NAD+ kinase; Chemistry; Biochemistry; Biology; Cell biology; Molecular biology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001186906,0.000450753,0.000537946,0.00009656377,0.0003619814,0.0001221042,0.0004949552,0.0004230009,0.00003245349],"category_scores_gemma":[0.0001735138,0.000447096,0.0002795467,0.00008222544,0.0007819547,0.00003011188,0.0001633023,0.0002154253,0.00000596978],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001575345,"about_ca_system_score_gemma":0.00009379129,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000318794,"about_ca_topic_score_gemma":0.0001597828,"domain_scores_codex":[0.997658,0.000222039,0.0006234927,0.0008608504,0.0002302599,0.0004054042],"domain_scores_gemma":[0.9979153,0.0000653043,0.0005619805,0.001127503,0.000124822,0.0002051043],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002398176,0.000242076,0.000007126777,0.00002998328,0.0001533551,0.000006357108,0.0003099927,0.00002269322,0.9940855,0.0001594772,0.002281131,0.0003041487],"study_design_scores_gemma":[0.003044593,0.0007840637,0.001327593,0.00004474329,0.0001542565,0.000009415978,0.0001332822,0.0004235691,0.9906302,0.0001645301,0.002795505,0.000488219],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931867,0.00006827433,0.0008954078,0.001741446,0.0008361998,0.0003418873,0.002425148,0.00004443081,0.0004604976],"genre_scores_gemma":[0.9930111,0.0005426174,0.002917948,0.0003494913,0.0007262822,0.00001670626,0.002153819,0.00006453543,0.0002175358],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003455254,"threshold_uncertainty_score":0.9997981,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01956955904467415,"score_gpt":0.2590586971654817,"score_spread":0.2394891381208076,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}