{"id":"W2750851336","doi":"10.3390/membranes7030049","title":"Membrane-Accelerated Amyloid-β Aggregation and Formation of Cross-β Sheets","year":2017,"lang":"en","type":"article","venue":"Membranes","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Lipid bilayer; Bilayer; Biophysics; Membrane; Chemistry; Amyloid (mycology); Membrane fluidity; Protein aggregation; Biological membrane; Amyloid fibril; Amyloid β; Biochemistry; Biology; Disease; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001530839,0.0002505362,0.0002231975,0.0003365313,0.0001654312,0.0003037482,0.0001062986,0.000271143,0.0006272182],"category_scores_gemma":[0.0001500753,0.00009861957,0.0002288636,0.0002003559,0.0001723617,0.000420871,0.0002521281,0.0003582501,0.0002445205],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00020395,"about_ca_system_score_gemma":0.0001076551,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001723016,"about_ca_topic_score_gemma":0.0001827987,"domain_scores_codex":[0.9999297,0.00001650017,0.000007005077,0.0000159628,0.00002047366,0.00001030856],"domain_scores_gemma":[0.9999131,0.00001208667,0.00004267097,0.000004476565,0.00001581105,0.0000117565],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001159656,0.00005420982,0.002379414,0.0004322944,0.00005151176,0.0006770747,0.0000902662,0.0002713217,0.9777099,0.001434804,0.000334517,0.01644869],"study_design_scores_gemma":[0.00001647334,0.0006735019,0.03389679,0.000109368,0.0001018685,0.005620872,0.0002087739,0.001320913,0.9347907,0.003082987,0.02014705,0.00003072252],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8467057,0.1329472,0.01351839,0.0007667164,0.0002148957,0.00005896791,0.0003820926,0.0002050358,0.005201038],"genre_scores_gemma":[0.9516675,0.04303565,0.003098482,0.0001882909,0.0000779459,0.00001732153,0.000185647,0.000009519056,0.001719604],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006272182,"threshold_uncertainty_score":0.002098262,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05476115336363765,"score_gpt":0.3590900416490616,"score_spread":0.3043288882854239,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}