{"id":"W2750864670","doi":"10.1021/acs.orglett.7b02476","title":"Scalable Synthesis of a Key Intermediate for the Production of Pleuromutilin-Based Antibiotics","year":2017,"lang":"en","type":"article","venue":"Organic Letters","topic":"Veterinary medicine and infectious diseases","field":"Veterinary","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Yale University","keywords":"Chemistry; Yield (engineering); Combinatorial chemistry; Reagent; Antibiotics; Key (lock); Catalysis; Scalability; Organic chemistry; Computer science; Database; Biochemistry; Computer security","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000291417,0.0004632734,0.0002867967,0.0002523989,0.0001941485,0.000250791,0.0004368981,0.0004066498,0.001662832],"category_scores_gemma":[0.000281844,0.0001822856,0.0002023599,0.0001680856,0.0001934034,0.0004997954,0.0005382013,0.0007559079,0.0008577654],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003841355,"about_ca_system_score_gemma":0.0004098727,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003049236,"about_ca_topic_score_gemma":0.0008735695,"domain_scores_codex":[0.9998071,0.00002780513,0.00001873214,0.0000371824,0.00006959982,0.00003961943],"domain_scores_gemma":[0.9998981,0.00001877316,0.00002122259,0.00001324078,0.00001803523,0.00003072789],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005131683,0.00006116359,0.00009108717,0.0002290523,0.00001045241,0.0003920997,0.00006397645,0.0005492977,0.9896411,0.001159346,0.0002393622,0.007511701],"study_design_scores_gemma":[0.00002526311,0.0004087725,0.0006085586,0.00002479944,0.00001794931,0.0005426013,0.00003118939,0.00138476,0.9818704,0.0002689443,0.01479766,0.00001917744],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7976549,0.00832553,0.1600709,0.0008590682,0.0003602308,0.0007991259,0.001519209,0.0009581516,0.02945297],"genre_scores_gemma":[0.9201428,0.003274651,0.07070972,0.0001090926,0.00003518319,0.0001920304,0.0009190548,0.00007727118,0.004540109],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001662832,"threshold_uncertainty_score":0.005562663,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04099454761947837,"score_gpt":0.2942863029339272,"score_spread":0.2532917553144489,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}