{"id":"W2750878276","doi":"10.1101/184945","title":"A transcriptome-wide association study identifies <i>PALMD</i> as a susceptibility gene for calcific aortic valve stenosis","year":2017,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cardiac Valve Diseases and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval","keywords":"Genome-wide association study; Biobank; Expression quantitative trait loci; Genetic association; Candidate gene; Quantitative trait locus; Genetics; Biology; Population; Transcriptome; Mendelian randomization; Disease; Allele; Gene; Medicine; Internal medicine; Single-nucleotide polymorphism; Genetic variants; Gene expression; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004271816,0.0003021709,0.0003700526,0.0006486949,0.0004606135,0.000629689,0.0002581393,0.0005158989,0.002569472],"category_scores_gemma":[0.0009970949,0.0001707726,0.0005435533,0.000808634,0.0003475618,0.0001126102,0.0004081813,0.000645052,0.0002954468],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001437307,"about_ca_system_score_gemma":0.000165838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001481088,"about_ca_topic_score_gemma":0.001586352,"domain_scores_codex":[0.9997035,0.00005831457,0.00002363221,0.0001152771,0.00006265309,0.00003663099],"domain_scores_gemma":[0.9993533,0.0002197142,0.0002119168,0.00006016261,0.00005091061,0.0001039301],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002181145,0.000210495,0.6668083,0.0002843444,0.001721174,0.00468749,0.0003468848,0.0005101435,0.3058133,0.0003792439,0.002496966,0.01456056],"study_design_scores_gemma":[0.00005358604,0.0001015366,0.9923466,0.00001947102,0.0004422692,0.001895197,0.00008149168,0.0008018594,0.003024208,0.0001930203,0.001029333,0.00001141331],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958501,0.0007169408,0.001275908,0.0002129007,0.00003641526,0.000009871304,0.001196578,0.00005185474,0.0006493552],"genre_scores_gemma":[0.9969379,0.0003511179,0.001074805,0.000158634,0.00003452768,0.00001168148,0.0009842227,0.00001508862,0.0004320682],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002569472,"threshold_uncertainty_score":0.008595705,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02191180501468287,"score_gpt":0.3061091554194481,"score_spread":0.2841973504047652,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}