{"id":"W2750919339","doi":"10.1186/s12885-017-3639-0","title":"Inhibition of PI3K-AKT-mTOR pathway sensitizes endometrial cancer cell lines to PARP inhibitors","year":2017,"lang":"en","type":"article","venue":"BMC Cancer","topic":"Endometrial and Cervical Cancer Treatments","field":"Medicine","cited_by":106,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; McGill University","funders":"Israel Cancer Research Fund","keywords":"PTEN; PI3K/AKT/mTOR pathway; Olaparib; PARP inhibitor; Cancer research; Tensin; Endometrial cancer; Protein kinase B; Biology; Cancer; Poly ADP ribose polymerase; Cell biology; Signal transduction; Genetics; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001949893,0.0003371446,0.0003819786,0.0002870516,0.0001391552,0.0002451464,0.0002443467,0.0002244549,0.001484094],"category_scores_gemma":[0.0001403038,0.0001624643,0.0003420085,0.0003127542,0.0001132992,0.0001485983,0.0001635425,0.0005077609,0.000480061],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001859534,"about_ca_system_score_gemma":0.000210878,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004081254,"about_ca_topic_score_gemma":0.0006957156,"domain_scores_codex":[0.9998185,0.00002654399,0.00003549892,0.0000281466,0.00005689789,0.00003441644],"domain_scores_gemma":[0.9999229,0.00001894864,0.00001600045,0.00001484929,0.0000148102,0.00001255165],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004885111,0.0002513059,0.001139221,0.0003215214,0.00005303608,0.0001783648,0.00004789812,0.0005291087,0.9873263,0.0001747795,0.00067519,0.008814549],"study_design_scores_gemma":[0.00007384708,0.001661802,0.006660819,0.0000214319,0.00006999652,0.0005845734,0.00003271626,0.001564321,0.9821946,0.00006192395,0.007065052,0.000008771342],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9740396,0.01324805,0.005269061,0.000319321,0.0001625525,0.0001772746,0.002175308,0.0002911338,0.0043177],"genre_scores_gemma":[0.9806261,0.006840899,0.006199086,0.0001901361,0.00003378639,0.0002166681,0.003235297,0.00002793084,0.002630178],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001484094,"threshold_uncertainty_score":0.004964769,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04759217729314959,"score_gpt":0.329632885682435,"score_spread":0.2820407083892854,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}