{"id":"W2750955292","doi":"10.1152/ajpendo.00151.2017","title":"Oleate activates SREBP-1 signaling activity in <i>SCD1</i>-deficient hepatocytes","year":2017,"lang":"en","type":"article","venue":"American Journal of Physiology-Endocrinology and Metabolism","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Fonds de recherche du Québec – Nature et technologies; National Institutes of Health; Government of Canada; Natural Sciences and Engineering Research Council of Canada; Université du Québec à Montréal; U.S. Department of Agriculture; American Diabetes Association","keywords":"Lipogenesis; Sterol regulatory element-binding protein; Fatty acid synthesis; Chemistry; Transcription factor; Lipid metabolism; Carbohydrate-responsive element-binding protein; De novo synthesis; Fatty acid; Biochemistry; Biology; Cell biology; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004172774,0.0003119831,0.001475618,0.0003452241,0.0002794935,0.00003567213,0.0003331292,0.00009348329,0.00003368833],"category_scores_gemma":[0.00032549,0.0002359388,0.0002391835,0.0001167886,0.001340886,0.0003507697,0.0001830516,0.0009731053,0.000008257202],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002684208,"about_ca_system_score_gemma":0.0001274394,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002372845,"about_ca_topic_score_gemma":0.000008255077,"domain_scores_codex":[0.9979662,0.0003127862,0.0005223962,0.0003827002,0.0001885777,0.0006273394],"domain_scores_gemma":[0.9977965,0.000205124,0.001078611,0.0005114785,0.0001677142,0.000240521],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001366285,0.0003109516,0.02338816,0.00003047027,0.0002217059,0.00009347493,0.0004314802,0.00001431883,0.8622138,0.0004179997,0.00004344144,0.1114679],"study_design_scores_gemma":[0.003371369,0.0004322095,0.890411,0.00008948351,0.000242348,0.0007515283,0.0004073707,0.00002714363,0.09289858,0.0004179559,0.01074131,0.0002096606],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946306,0.002222219,0.00002700346,0.001931439,0.0007325092,0.0001542952,0.000006293239,0.00001927498,0.0002763542],"genre_scores_gemma":[0.9954753,0.002487713,0.0005522021,0.0006913844,0.0006872455,0.000008972144,0.000001209711,0.00002455926,0.00007143633],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8670229,"threshold_uncertainty_score":0.9621305,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01637867399576694,"score_gpt":0.2835570300437115,"score_spread":0.2671783560479445,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}