{"id":"W2751083008","doi":"10.1371/journal.pone.0183959","title":"Bromide supplementation exacerbated the renal dysfunction, injury and fibrosis in a mouse model of Alport syndrome","year":2017,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Japan Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology; Kidney Foundation of Canada; Pharmaceutical Society of Japan; Alport Syndrome Foundation","keywords":"Alport syndrome; Internal medicine; Endocrinology; Renal function; Blood urea nitrogen; Creatinine; Glomerulosclerosis; Basement membrane; Fibrosis; Proteinuria; Type IV collagen; Glomerular basement membrane; Bromide; Acute kidney injury; Medicine; Chemistry; Kidney; Glomerulonephritis; Pathology; Extracellular matrix; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003974413,0.001173623,0.00110022,0.001163315,0.000299716,0.0003865787,0.0004137874,0.001053315,0.001428157],"category_scores_gemma":[0.000180867,0.0004659267,0.0008258349,0.0003668708,0.0004626098,0.0004953074,0.0002948078,0.001827188,0.0002800929],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00030614,"about_ca_system_score_gemma":0.000363809,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009960126,"about_ca_topic_score_gemma":0.001439146,"domain_scores_codex":[0.9995264,0.0001041421,0.00006429511,0.00009657705,0.0001230359,0.00008543663],"domain_scores_gemma":[0.9996241,0.00002581235,0.0001284161,0.00002732455,0.00003467679,0.0001596015],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001152708,0.0004258901,0.0004614519,0.0001001742,0.0000327497,0.0002713214,0.00004880072,0.00008492018,0.9959717,0.0000652674,0.00005418351,0.001330695],"study_design_scores_gemma":[0.000330984,0.01212544,0.01190661,0.00004864646,0.0002178558,0.001183397,0.0001671767,0.001510523,0.9689575,0.000194086,0.003321405,0.00003636474],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941035,0.00236227,0.001685478,0.000262495,0.00007699959,0.0000744187,0.0004268044,0.0002260066,0.0007819803],"genre_scores_gemma":[0.9866688,0.003125847,0.003312287,0.0002964759,0.0000514835,0.0001550593,0.0007028519,0.00004721508,0.005639887],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001428157,"threshold_uncertainty_score":0.00477767,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06213966548863268,"score_gpt":0.2971882408068151,"score_spread":0.2350485753181824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}