{"id":"W2751258666","doi":"10.1038/nprot.2017.089","title":"Use of a neonatal rat system as a bioincubator to generate adult-like mature cardiomyocytes from human and mouse pluripotent stem cells","year":2017,"lang":"en","type":"article","venue":"Nature Protocols","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"Nexen (Canada)","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Heart, Lung, and Blood Institute","keywords":"Induced pluripotent stem cell; Embryonic stem cell; Biology; Cell biology; Stem cell; Progenitor cell; Directed differentiation; Myocyte; Cellular differentiation; Cell type; In vivo; Cell; Neuroscience; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001640667,0.001097949,0.0004673888,0.0009953111,0.0004969803,0.0005025669,0.001071554,0.0006828106,0.005066542],"category_scores_gemma":[0.0005433435,0.0003315997,0.0007133934,0.0003148732,0.0005525405,0.000819155,0.0005626485,0.001195577,0.001797797],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000348216,"about_ca_system_score_gemma":0.001334314,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001331585,"about_ca_topic_score_gemma":0.003095001,"domain_scores_codex":[0.9992059,0.0001476468,0.0001336799,0.000200162,0.0002094937,0.0001032051],"domain_scores_gemma":[0.9989656,0.0001646389,0.0002127891,0.0002373173,0.0001874665,0.000232122],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002227836,0.00006014717,0.0003777985,0.0001176978,0.0000234255,0.0001615849,0.00004927014,0.000110109,0.9885228,0.0009317363,0.0003411026,0.009081424],"study_design_scores_gemma":[0.00003032056,0.0005135974,0.001486671,0.00003225191,0.00008129128,0.0005241249,0.00003045259,0.0003666873,0.9871883,0.00007015483,0.009662458,0.00001361886],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.7400264,0.009087117,0.2141885,0.001190599,0.002107436,0.002401453,0.004470769,0.003043709,0.02348401],"genre_scores_gemma":[0.6608485,0.008339531,0.2895535,0.000711456,0.0002302111,0.002649543,0.005023472,0.0006478616,0.03199589],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.005066542,"threshold_uncertainty_score":0.0169493,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01969493648616957,"score_gpt":0.3001359543269539,"score_spread":0.2804410178407843,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}