{"id":"W2751279163","doi":"10.1016/j.reprotox.2017.08.019","title":"Valproic acid increases NF-κB transcriptional activation despite decreasing DNA binding ability in P19 cells, which may play a role in VPA-initiated teratogenesis","year":2017,"lang":"en","type":"article","venue":"Reproductive Toxicology","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research","keywords":"Transcription factor; Molecular biology; Nuclear protein; P50; NFKB1; Gene expression; Protein subunit; NF-κB; Biology; DNA; DNA-binding protein; Chemistry; Cell biology; Gene; Signal transduction; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001255203,0.0003199349,0.0003943115,0.0002577486,0.0002878867,0.00006806016,0.0003914857,0.0004131059,0.00004657529],"category_scores_gemma":[0.001878881,0.0003531273,0.00009874583,0.0002441066,0.0002247029,0.00004816772,0.0001547093,0.0002852419,0.00001273613],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000244657,"about_ca_system_score_gemma":0.0003841222,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004448931,"about_ca_topic_score_gemma":0.001008245,"domain_scores_codex":[0.9968394,0.0005859783,0.0004858823,0.001376327,0.0001865818,0.0005258127],"domain_scores_gemma":[0.9982818,0.00006436682,0.0003014502,0.001021469,0.0002273687,0.0001035686],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005035658,0.0004795367,0.0953503,0.00002581457,0.00004936803,0.00001382252,0.0002558717,0.00013286,0.9023149,0.00006848935,0.00001304777,0.0007924357],"study_design_scores_gemma":[0.000986763,0.0002089209,0.1922958,0.00004623406,0.00001827676,0.00003036935,0.0001132416,0.00005358094,0.8053649,0.0003513084,0.000239855,0.0002907989],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980471,0.000236044,0.000158719,0.0003917779,0.000206205,0.0006121087,0.00005500735,0.00002995629,0.0002631501],"genre_scores_gemma":[0.9981341,0.00003794092,0.001017872,0.00008181125,0.0003130441,0.0001411742,0.0001813694,0.00004562758,0.00004699787],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09694999,"threshold_uncertainty_score":0.9998921,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03269819949831162,"score_gpt":0.286883959317311,"score_spread":0.2541857598189994,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}