{"id":"W2751288167","doi":"10.1038/s41598-017-11829-2","title":"Selective tubular activation of hypoxia-inducible factor-2α has dual effects on renal fibrosis","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute","funders":"National Research Foundation of Korea; Ewha Womans University; NIH Clinical Center; Yonsei University; National Research Foundation; Clinical Trial Center, China Medical University Hospital","keywords":"Hypoxia-inducible factors; Hypoxia (environmental); Fibrosis; Kidney; Downregulation and upregulation; Fibronectin; Internal medicine; Kidney disease; Medicine; Endocrinology; Cancer research; Chemistry; Biology; Cell biology; Biochemistry; Extracellular matrix","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004675738,0.0001734583,0.0002239182,0.00009778806,0.0006452918,0.000230001,0.000173012,0.0001619148,0.00001891967],"category_scores_gemma":[0.000582972,0.0001594489,0.0001510385,0.0001041624,0.0002688641,0.00002194462,0.0001139836,0.0001026481,0.000005263281],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002422257,"about_ca_system_score_gemma":0.0002815423,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008054687,"about_ca_topic_score_gemma":0.00002209946,"domain_scores_codex":[0.998205,0.00004765682,0.0002923686,0.0007880151,0.0003879974,0.0002789417],"domain_scores_gemma":[0.9977308,0.0000139069,0.0005164683,0.001402421,0.0002330633,0.0001033535],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005791505,0.00005600065,0.0007536736,0.00002644185,0.00004487162,0.000004978509,0.00008820876,0.00002125584,0.9749259,0.00001251255,0.01938063,0.004627614],"study_design_scores_gemma":[0.0002490145,0.0001443072,0.01841999,0.00004900343,0.00001674281,0.00001997431,0.000008149569,0.00000412084,0.8592184,0.000317682,0.1214012,0.0001514808],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908155,0.0002148338,0.0001674441,0.00009443639,0.006952333,0.0003148789,0.00001181849,0.00001313598,0.001415605],"genre_scores_gemma":[0.9956713,0.00001469906,0.0001961227,0.00002447755,0.0008321035,0.00002268036,0.0000991679,0.00001953612,0.003119866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1157076,"threshold_uncertainty_score":0.6502137,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01820239375564531,"score_gpt":0.2604271122575634,"score_spread":0.2422247185019181,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}