{"id":"W2751298042","doi":"10.1186/s40478-017-0473-1","title":"Effects of sustained i.c.v. infusion of lupus CSF and autoantibodies on behavioral phenotype and neuronal calcium signaling","year":2017,"lang":"en","type":"article","venue":"Acta Neuropathologica Communications","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja; Ontario Mental Health Foundation","keywords":"Systemic lupus erythematosus; Autoantibody; Phenotype; Neurology; Medicine; Calcium; Signal transduction; Calcium signaling; Neuroscience; Immunology; Endocrinology; Pharmacology; Internal medicine; Biology; Cell biology; Antibody; Biochemistry; Gene; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002538362,0.0008840304,0.0008296639,0.0003945314,0.0001873732,0.0004089738,0.0004026887,0.0006994088,0.0006797428],"category_scores_gemma":[0.0002727559,0.0002008528,0.0003985106,0.0002155372,0.0006054845,0.0003677373,0.0002599987,0.00146531,0.0001855407],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004097737,"about_ca_system_score_gemma":0.00055712,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008491178,"about_ca_topic_score_gemma":0.001421197,"domain_scores_codex":[0.9997397,0.00003710417,0.00002493356,0.00005819529,0.00003506866,0.0001049929],"domain_scores_gemma":[0.9996281,0.00006184932,0.0001014017,0.00003464533,0.00002613561,0.0001479149],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00839513,0.001292442,0.0005438814,0.00009067384,0.00002853924,0.0002445834,0.00006259355,0.0001758393,0.983229,0.0000790109,0.0001397792,0.005718536],"study_design_scores_gemma":[0.0007242805,0.03065069,0.01151964,0.00002873743,0.0001090387,0.0005126116,0.0001073913,0.001543862,0.9530004,0.0001101973,0.001662898,0.00003029187],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975467,0.000982923,0.0004202376,0.00009440348,0.00007124318,0.00004830955,0.0003394585,0.00008684134,0.0004099246],"genre_scores_gemma":[0.9953759,0.0008958954,0.001505296,0.0001433035,0.00006569026,0.0001704913,0.0005040723,0.00002707499,0.001312225],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008840304,"threshold_uncertainty_score":0.00297308,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06348095942379835,"score_gpt":0.3622063672216115,"score_spread":0.2987254077978131,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}