{"id":"W2751430583","doi":"10.1038/ng.3949","title":"Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis","year":2017,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":517,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre; McGill University; University of Toronto; Jewish General Hospital","funders":"National Health and Medical Research Council; Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Medical Research Council; Versus Arthritis; National Institute for Health and Care Research; Jewish General Hospital; Ernest Heine Family Foundation; Uppsala Universitet; Vetenskapsrådet; ZonMw; European Commission; Genome Canada; British Heart Foundation; Wellcome Trust","keywords":"Biology; Genome-wide association study; Single-nucleotide polymorphism; Phenotype; Genetics; Osteoporosis; Genetic association; Gene; Quantitative trait locus; Candidate gene; Bone mineral; Expression quantitative trait loci; Endocrinology; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003390639,0.0001044322,0.0002075407,0.00004270128,0.00006720791,0.000009945758,0.0001072431,0.0003641158,0.000003823205],"category_scores_gemma":[0.0003851725,0.00009716111,0.0000406665,0.00004853229,0.0001156947,0.000002923356,0.00009133134,0.0001254905,2.782855e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001805403,"about_ca_system_score_gemma":0.00009202552,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004950653,"about_ca_topic_score_gemma":0.000948991,"domain_scores_codex":[0.9991273,0.00004772015,0.0003149949,0.0002353604,0.0001357881,0.0001388206],"domain_scores_gemma":[0.9989066,0.00001698095,0.0004775603,0.0003412986,0.0002114236,0.00004615797],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00006590331,0.00007088226,0.7720575,0.0000135739,0.00006412766,5.265021e-7,0.00006214339,0.0002529668,0.2249381,0.00001734394,0.001410952,0.001046019],"study_design_scores_gemma":[0.000781816,0.0001673927,0.9377818,0.00001134718,0.00003623644,0.000002052186,0.0000494128,0.00014063,0.06053461,0.0002092986,0.0001938296,0.0000915618],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99773,0.001233267,0.0005223066,0.0002109585,0.00009277629,0.0001311261,0.00002577927,0.000001879064,0.00005187745],"genre_scores_gemma":[0.9977565,0.0002588247,0.001265372,0.00008352483,0.00006958489,0.00000411603,0.0001689912,0.000009095063,0.0003840244],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1657243,"threshold_uncertainty_score":0.3962115,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01253517862794562,"score_gpt":0.2525917661583964,"score_spread":0.2400565875304508,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}