{"id":"W2751430583","doi":"10.1038/ng.3949","title":"Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis","year":2017,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":517,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre; McGill University; University of Toronto; Jewish General Hospital","funders":"National Health and Medical Research Council; Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Medical Research Council; Versus Arthritis; National Institute for Health and Care Research; Jewish General Hospital; Ernest Heine Family Foundation; Uppsala Universitet; Vetenskapsrådet; ZonMw; European Commission; Genome Canada; British Heart Foundation; Wellcome Trust","keywords":"Biology; Genome-wide association study; Single-nucleotide polymorphism; Phenotype; Genetics; Osteoporosis; Genetic association; Gene; Quantitative trait locus; Candidate gene; Bone mineral; Expression quantitative trait loci; Endocrinology; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003636589,0.000431188,0.0005074998,0.001662543,0.0004363654,0.0005218253,0.0005721822,0.0007614085,0.002753128],"category_scores_gemma":[0.001331255,0.0002298393,0.0006249317,0.0017001,0.000407528,0.0001583193,0.0003279149,0.000599389,0.0003162005],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000242967,"about_ca_system_score_gemma":0.0001925713,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002868855,"about_ca_topic_score_gemma":0.002371233,"domain_scores_codex":[0.999575,0.00007016059,0.00004511817,0.0001095317,0.0001341393,0.00006605733],"domain_scores_gemma":[0.9990891,0.000453669,0.0001991974,0.00007152836,0.00007134918,0.0001151021],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004475738,0.0002803074,0.6714764,0.0002602095,0.00110349,0.01821272,0.001018299,0.001284632,0.2616375,0.001119067,0.001041301,0.03809035],"study_design_scores_gemma":[0.0001840239,0.0002875969,0.9657878,0.00003358427,0.0003875039,0.01031617,0.0001700379,0.00154024,0.01812441,0.0005041089,0.002631149,0.0000332177],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976007,0.0003859285,0.0008776022,0.00006070405,0.00001388278,0.00001317234,0.000533818,0.00001685017,0.0004973745],"genre_scores_gemma":[0.9970604,0.0001654591,0.001294993,0.00004873233,0.00002145011,0.00001261171,0.0006655368,0.000012252,0.0007185858],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002868855,"threshold_uncertainty_score":0.009210169,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01253517862794562,"score_gpt":0.2525917661583964,"score_spread":0.2400565875304508,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}