{"id":"W2751439404","doi":"10.1021/acs.biochem.7b00298","title":"Characterization of Hsp90 Co-Chaperone p23 Cleavage by Caspase-7 Uncovers a Peptidase–Substrate Interaction Involving Intrinsically Disordered Regions","year":2017,"lang":"en","type":"article","venue":"Biochemistry","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Fonds de recherche du Québec – Nature et technologies; Natural Sciences and Engineering Research Council of Canada","keywords":"Cleavage (geology); Poly ADP ribose polymerase; Proteolysis; Caspase; Chemistry; Biochemistry; Caspase 3; Polymerase; Biophysics; Chaperone (clinical); Cell biology; Molecular biology; Enzyme; Biology; Apoptosis; Programmed cell death","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009500272,0.0002997341,0.0001748637,0.0001431281,0.0001481999,0.0002206436,0.0002401961,0.0002107526,0.0007656143],"category_scores_gemma":[0.0001814397,0.0000796247,0.0003011244,0.0001793907,0.0001396766,0.0001850542,0.0001517121,0.0004500997,0.0004209813],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003105892,"about_ca_system_score_gemma":0.0001336841,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004752535,"about_ca_topic_score_gemma":0.0004151883,"domain_scores_codex":[0.9998701,0.00001926262,0.000009030776,0.00001969584,0.00005125258,0.00003064462],"domain_scores_gemma":[0.9998829,0.00001543988,0.0000360901,0.00001091762,0.00001836552,0.00003619533],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006173597,0.0000227268,0.0003572014,0.00001413344,0.000006920516,0.0001674564,0.000007437329,0.0001362215,0.9986975,0.00005771049,0.00001964926,0.0004512072],"study_design_scores_gemma":[0.00001276568,0.0002719147,0.007308973,0.000004070623,0.00001508446,0.001284489,0.00004806639,0.002705669,0.9867741,0.00007938757,0.001488106,0.000007303861],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976804,0.0003258343,0.001509019,0.00003087402,0.000004922893,0.000009110438,0.0001584914,0.00001358342,0.0002677231],"genre_scores_gemma":[0.9974687,0.0002452639,0.001175114,0.0000203287,0.000003210776,0.00001030425,0.0005415196,0.000007788539,0.0005277597],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007656143,"threshold_uncertainty_score":0.002561271,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01764327418931084,"score_gpt":0.2954785655211962,"score_spread":0.2778352913318853,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}