{"id":"W2751527074","doi":"10.1016/j.neulet.2017.08.060","title":"Catechol-O-Methyltransferase gene (val158met) polymorphisms and anxious symptoms in early childhood: The roles of hypothalamus-pituitary-adrenal axis reactivity and life stress","year":2017,"lang":"en","type":"article","venue":"Neuroscience Letters","topic":"Stress Responses and Cortisol","field":"Neuroscience","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; Ontario Mental Health Foundation","keywords":"Catechol-O-methyl transferase; Hypothalamus; Hypothalamic–pituitary–adrenal axis; Endocrinology; Reactivity (psychology); Internal medicine; Psychology; Medicine; Gene; Hormone; Allele; Biology; Genetics; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002007429,0.0005215657,0.0003439878,0.0003103725,0.0003316733,0.0004810005,0.0002847258,0.0006800474,0.001690742],"category_scores_gemma":[0.0008501338,0.0002982367,0.0003906483,0.0002904382,0.0002612257,0.0002443847,0.000240886,0.0006458954,0.0001001604],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002392471,"about_ca_system_score_gemma":0.0002465397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00614147,"about_ca_topic_score_gemma":0.00911102,"domain_scores_codex":[0.9998683,0.00004051623,0.00001015566,0.0000332428,0.00001818259,0.00002962157],"domain_scores_gemma":[0.9995854,0.0001194845,0.0001510214,0.00001854136,0.00001984797,0.0001056887],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008140834,0.0001366265,0.9838991,0.00004541801,0.0002646907,0.001293128,0.0005826207,0.00007005077,0.008559643,0.00015919,0.0001816379,0.0039938],"study_design_scores_gemma":[0.000008591536,0.00005039083,0.9987144,0.00001082472,0.00006897772,0.0005408836,0.0001876715,0.00006446487,0.0001996043,0.00006417747,0.00008703483,0.000002971677],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987997,0.0006188467,0.00006302288,0.0001582874,0.00001303283,0.000001535765,0.00007206305,0.000001556011,0.0002718988],"genre_scores_gemma":[0.9992529,0.0003098351,0.00008136489,0.00004111301,0.00001489776,0.000003451104,0.00005838258,0.000002114189,0.0002360007],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00614147,"threshold_uncertainty_score":0.0122115,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01731103697228384,"score_gpt":0.2401754832306618,"score_spread":0.222864446258378,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}