{"id":"W2751623674","doi":"10.1038/s41598-017-10741-z","title":"Disease mutations reveal residues critical to the interaction of P4-ATPases with lipid substrates","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Eye Institute; Novo Nordisk Fonden; National Institutes of Health; H. Lundbeck A/S; Lundbeckfonden; Medical Research Council; Aarhus Universitet; Novo Nordisk; Sundhed og Sygdom, Det Frie Forskningsråd","keywords":"Flippase; Phosphatidylserine; Chemistry; P-type ATPase; ATPase; Transmembrane domain; Arginine; Biophysics; Phospholipid; Chromosomal translocation; Transmembrane protein; Biochemistry; ATP-binding cassette transporter; Phosphatidylcholine; Cell biology; Biology; Membrane; Amino acid; Transporter; Enzyme; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001673723,0.0007432806,0.0002891292,0.0002164355,0.0002252118,0.0003130378,0.000274138,0.0009397549,0.001175589],"category_scores_gemma":[0.0002777207,0.0001443525,0.0003116422,0.0001543573,0.0003748621,0.0001631858,0.0003056052,0.0004764164,0.0005031367],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002034555,"about_ca_system_score_gemma":0.0001469071,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004586866,"about_ca_topic_score_gemma":0.0004894422,"domain_scores_codex":[0.9998511,0.00003715111,0.00002788935,0.00003541324,0.00003025712,0.00001815464],"domain_scores_gemma":[0.9998088,0.00005381669,0.00007066403,0.00001243428,0.00001213099,0.00004210795],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008038517,0.0002189619,0.005948619,0.00009413581,0.00005389777,0.006135353,0.0001255999,0.0007599067,0.9774846,0.0006407792,0.0002706979,0.007463475],"study_design_scores_gemma":[0.0002513674,0.001295446,0.05366371,0.00006859248,0.0001743657,0.02853919,0.0002190432,0.006397332,0.9036371,0.0009374653,0.004764616,0.00005189076],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969995,0.0003244932,0.0017749,0.00006029738,0.00002563335,0.00002633228,0.0002106111,0.00004710017,0.0005311078],"genre_scores_gemma":[0.9978634,0.0001183936,0.001419106,0.00002857328,0.00001067347,0.00001143019,0.0001592913,0.0000144463,0.0003746561],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001175589,"threshold_uncertainty_score":0.003932714,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01659106732314021,"score_gpt":0.308474786129374,"score_spread":0.2918837188062338,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}