{"id":"W2751649617","doi":"10.1158/1078-0432.ccr-16-3066","title":"Immuno-oncology Clinical Trial Design: Limitations, Challenges, and Opportunities","year":2017,"lang":"en","type":"editorial","venue":"Clinical Cancer Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University College of the North","funders":"National Cancer Institute","keywords":"Dosing; Clinical trial; Medicine; Clinical study design; Intensive care medicine; Cancer; Immunotherapy; Oncology; Precision medicine; Internal medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","sts","research_integrity"],"consensus_categories":["metaresearch","research_integrity"],"category_scores_codex":[0.03623755,0.0004750742,0.00229799,0.0003672111,0.0005891684,0.0001916795,0.0009376512,0.004150494,0.0003927531],"category_scores_gemma":[0.02679566,0.0003980137,0.0007616279,0.00009754737,0.004461169,0.0001529818,0.0005250778,0.006371821,0.00005154103],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005726833,"about_ca_system_score_gemma":0.01726911,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003310901,"about_ca_topic_score_gemma":0.0004436403,"domain_scores_codex":[0.987869,0.005098272,0.002563447,0.001439218,0.002059685,0.000970343],"domain_scores_gemma":[0.9587525,0.03577537,0.0009001258,0.001852746,0.001957381,0.0007619275],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.1551325,0.0004096375,0.000006024536,0.0001553693,0.000576506,0.0001375171,0.00006615728,1.267047e-8,0.000003065473,0.00001809585,0.4719603,0.3715348],"study_design_scores_gemma":[0.07251761,0.01859035,0.0003565191,0.0008056182,0.0003125245,0.000007669758,0.000257805,0.000006233068,0.000003095571,0.0002221067,0.9065698,0.0003506125],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"editorial","genre_gemma":"review","genre_scores_codex":[0.0007816823,0.1780224,0.000007741365,0.01714066,0.791244,0.002960078,0.0001579891,0.00008145122,0.009604049],"genre_scores_gemma":[0.0001793727,0.5362309,0.0001286161,0.000193878,0.4522551,0.0005679458,0.0001308282,0.00007440624,0.01023894],"genre_candidate":"editorial","genre_consensus":null,"teacher_disagreement_score":0.4346095,"threshold_uncertainty_score":0.9998472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.8329008721661434,"score_gpt":0.6316473128910778,"score_spread":0.2012535592750656,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}