{"id":"W2751938171","doi":"10.1038/s41467-017-00547-y","title":"The Candida albicans transcription factor Cas5 couples stress responses, drug resistance and cell cycle regulation","year":2017,"lang":"en","type":"article","venue":"Nature Communications","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Institute of General Medical Sciences; Wellcome Trust; Canadian Institutes of Health Research; University of Rochester; Fundo para o Desenvolvimento das Ciências e da Tecnologia; Universidade de Macau; Creighton University; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Nebraska Department of Health and Human Services; U.S. Department of Health and Human Services","keywords":"Candida albicans; Antifungal drug; Transcription factor; Biology; Cell cycle; Echinocandins; Cell biology; Corpus albicans; Transcriptional regulation; Cell; Microbiology; Gene; Genetics; Antifungal","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001220968,0.0003267518,0.0001860811,0.0002924942,0.0003631597,0.000786325,0.0003331285,0.0003383086,0.001303104],"category_scores_gemma":[0.0002325955,0.0001220259,0.0002351313,0.0001633388,0.0004194853,0.0003988603,0.0004237868,0.000409808,0.0003503445],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008182945,"about_ca_system_score_gemma":0.0004506078,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001840518,"about_ca_topic_score_gemma":0.002665132,"domain_scores_codex":[0.9998286,0.00001348594,0.00000925992,0.00004824031,0.00005794072,0.00004247394],"domain_scores_gemma":[0.9998966,0.00001165255,0.00002567599,0.00001160428,0.00002338976,0.00003112851],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001933505,0.00001688535,0.002211997,0.00006704853,0.00001067852,0.000157989,0.00005066313,0.0004719055,0.9813817,0.002416424,0.0005147969,0.01250662],"study_design_scores_gemma":[0.00002371019,0.0001669025,0.01687084,0.00002412366,0.0000223418,0.0004561513,0.0001440099,0.006091064,0.9593604,0.001368128,0.01544632,0.00002604852],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9524729,0.01018858,0.01781837,0.001559782,0.0002758919,0.00006570385,0.0006105973,0.0005730921,0.01643506],"genre_scores_gemma":[0.9944947,0.001037102,0.00218179,0.000123819,0.00002057062,0.000007761454,0.0001864774,0.00001543131,0.001932296],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001840518,"threshold_uncertainty_score":0.005937219,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02075527306758122,"score_gpt":0.3153208961305544,"score_spread":0.2945656230629732,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}