{"id":"W2751977187","doi":"10.1111/bcp.13428","title":"Pharmacokinetics of multiple doses of co‐crystal of tramadol–celecoxib: findings from a four‐way randomized open‐label phase I clinical trial","year":2017,"lang":"en","type":"article","venue":"British Journal of Clinical Pharmacology","topic":"Crystallography and molecular interactions","field":"Chemistry","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"BioPhage Pharma (Canada)","funders":"","keywords":"Tramadol; Pharmacokinetics; Celecoxib; Bioequivalence; Medicine; Dosing; Adverse effect; Pharmacology; Urology; Area under the curve; Anesthesia; Chemistry; Analgesic","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00460532,0.0002784726,0.003343153,0.000132262,0.0001687402,0.00008664902,0.001799912,0.0004971662,0.002466765],"category_scores_gemma":[0.009759755,0.0002937012,0.002126234,0.0000853215,0.001950705,0.0003292308,0.0003268985,0.001645865,0.000001509369],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000174216,"about_ca_system_score_gemma":0.000378374,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003817099,"about_ca_topic_score_gemma":0.0000536858,"domain_scores_codex":[0.9911446,0.001091414,0.006501801,0.0004161277,0.0004942085,0.0003518541],"domain_scores_gemma":[0.9826942,0.008547758,0.007131095,0.0003971065,0.0008376943,0.0003921489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5882288,0.01266711,0.001548007,0.0001120731,0.0036271,0.0006286234,0.00005458039,0.00001178801,0.3451457,0.000007582406,0.01187223,0.0360964],"study_design_scores_gemma":[0.8895169,0.001786018,0.0006582485,0.0004125553,0.002194433,0.0002932574,0.00005453889,0.0004933342,0.09447794,0.0002508019,0.009594946,0.0002669989],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923061,0.0007970147,0.0006930914,0.000214006,0.003445208,0.0005830232,0.000932469,0.00001006954,0.001019061],"genre_scores_gemma":[0.9913629,0.004551432,0.002306429,0.0001949815,0.001392166,0.00001996847,0.00003513756,0.00004057583,0.00009636002],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3012882,"threshold_uncertainty_score":0.9999515,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1726291492055129,"score_gpt":0.5052985966765698,"score_spread":0.332669447471057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}