{"id":"W2751988018","doi":"10.1083/jcb.201705085","title":"A neuroprotective agent that inactivates prodegenerative TrkA and preserves mitochondria","year":2017,"lang":"en","type":"article","venue":"The Journal of Cell Biology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Howard Hughes Medical Institute; Canada Research Chairs; Canadian Institutes of Health Research; Sick Kids Foundation; European Molecular Biology Organization; Hospital for Sick Children; Weston Brain Institute","keywords":"Wallerian degeneration; Axotomy; Biology; Degeneration (medical); Neuroprotection; Mitochondrion; Axon; Neuroscience; Tropomyosin receptor kinase A; Neurodegeneration; Cell biology; Nerve growth factor; Central nervous system; Receptor; Pathology; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008241767,0.0003585882,0.0002835255,0.0003998473,0.0001729737,0.0002094285,0.0002487746,0.0002294745,0.001128617],"category_scores_gemma":[0.00005446599,0.0000984342,0.000217948,0.0001849106,0.0001422578,0.0001912616,0.0001274913,0.0005399053,0.0002587484],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002797817,"about_ca_system_score_gemma":0.0002994833,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005308702,"about_ca_topic_score_gemma":0.002821903,"domain_scores_codex":[0.9999566,0.000003503573,0.000003854706,0.00000995706,0.00001066321,0.00001548606],"domain_scores_gemma":[0.9999728,0.000002463298,0.000006634255,0.000003255559,0.000004922807,0.000009917929],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001408214,0.00007771123,0.0001676329,0.00008985744,0.0000131274,0.00008920246,0.00001214419,0.0001114098,0.9864393,0.0001890031,0.0001092513,0.01256035],"study_design_scores_gemma":[0.00008273567,0.001406483,0.002311936,0.00001139247,0.0000377795,0.0005800414,0.00001235074,0.0002588032,0.9891887,0.00006282174,0.006040575,0.000006437715],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9744665,0.01339674,0.004653688,0.0002694296,0.00006940877,0.0001144535,0.0005863751,0.0002185489,0.006224858],"genre_scores_gemma":[0.9812227,0.008517513,0.005329498,0.0001322886,0.00002296211,0.0000465475,0.0007588923,0.00001422299,0.003955428],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001128617,"threshold_uncertainty_score":0.003775597,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02371999993418133,"score_gpt":0.2935880305759772,"score_spread":0.2698680306417959,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}