{"id":"W2752080846","doi":"10.1016/j.rvsc.2017.09.007","title":"A novel approach for scrapie-associated prion (PrPSc) detection in blood using the competitive affinity of an aggregate-specific antibody and streptavidin to PrPSc","year":2017,"lang":"en","type":"article","venue":"Research in Veterinary Science","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Food Inspection Agency","funders":"Canadian Food Inspection Agency","keywords":"Scrapie; Monoclonal antibody; Antibody; Streptavidin; Proteinase K; Immunoassay; Denaturation (fissile materials); Chemistry; Virology; Conjugate; Chronic wasting disease; Molecular biology; Biology; Biochemistry; Prion protein; Biotin; Immunology; Enzyme; Medicine; Pathology; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006517448,0.0009774077,0.0006512934,0.000600849,0.0002366596,0.0005872874,0.001054231,0.001107715,0.0006267136],"category_scores_gemma":[0.0006217551,0.0005657843,0.000477475,0.0003179165,0.0003593841,0.0003901978,0.0006042664,0.0009986151,0.0006383482],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003511519,"about_ca_system_score_gemma":0.0004649686,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007462224,"about_ca_topic_score_gemma":0.001684026,"domain_scores_codex":[0.9990844,0.0001662266,0.00004409501,0.0002469297,0.0003801864,0.00007828586],"domain_scores_gemma":[0.9996277,0.0001184578,0.00006062671,0.00003434362,0.0001070876,0.00005169053],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003542168,0.00003714954,0.0001589726,0.00005772119,0.00001026854,0.00003608911,0.00001740966,0.00003811748,0.9963822,0.00007874082,0.00006962052,0.003078287],"study_design_scores_gemma":[0.00002260519,0.000823439,0.001913187,0.000008336839,0.00003751279,0.0008969886,0.00002180373,0.00577882,0.9880761,0.00009593085,0.002292825,0.00003251034],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.4836694,0.004006251,0.506902,0.0005132218,0.000252509,0.0006930976,0.0004488793,0.001252246,0.002262411],"genre_scores_gemma":[0.5831419,0.001569551,0.4086184,0.0004708353,0.00008908843,0.0005026877,0.0007179991,0.00005647591,0.004833017],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001107715,"threshold_uncertainty_score":0.003446817,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1496315636142361,"score_gpt":0.4249516710013175,"score_spread":0.2753201073870815,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}