{"id":"W2752181067","doi":"10.1177/0022034517728497","title":"Defective Mineralization in X-Linked Hypophosphatemia Dental Pulp Cell Cultures","year":2017,"lang":"en","type":"article","venue":"Journal of Dental Research","topic":"Parathyroid Disorders and Treatments","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institutes of Health; Université Paris Descartes; National Institute for Health and Care Research; Ultragenyx Pharmaceutical; Agence Nationale de la Recherche; Fondation pour la Recherche Médicale; Réseau de Recherche en Santé Buccodentaire et Osseuse; McGill University","keywords":"PHEX; Osteopontin; DMP1; Hypophosphatemia; Chemistry; Osteomalacia; Von Kossa stain; Osteoid; Alkaline phosphatase; Osteoclast; Extracellular matrix; Hypophosphatemic Rickets; Extracellular; Mineralization (soil science); Internal medicine; Molecular biology; Endocrinology; Biology; Biochemistry; Rickets; Medicine; Vitamin D and neurology; Enzyme; Viral matrix protein; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003771723,0.0002610848,0.0004040624,0.0002441606,0.0002216773,0.0002950002,0.0002987469,0.0003247914,0.001365388],"category_scores_gemma":[0.0001353205,0.0001911039,0.0003068244,0.0002607877,0.0002329841,0.0001422185,0.0003769714,0.00047611,0.000479173],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002101096,"about_ca_system_score_gemma":0.0001955367,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001217239,"about_ca_topic_score_gemma":0.0015415,"domain_scores_codex":[0.9996214,0.00003501799,0.00005254488,0.00008144553,0.0001606416,0.00004893706],"domain_scores_gemma":[0.9997547,0.00006946985,0.0000352305,0.00005769742,0.00004844595,0.00003445386],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007252114,0.00003103098,0.0003031974,0.00004256339,0.000004575122,0.0001448585,0.00006866098,0.00006388206,0.9984249,0.00006005795,0.00001981863,0.0007640006],"study_design_scores_gemma":[0.0000205434,0.0002890598,0.007870028,0.00001290273,0.00002297761,0.0007393241,0.0000839263,0.00143705,0.98644,0.0000641377,0.003011112,0.000008969109],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889393,0.001648974,0.006681384,0.00003230142,0.00003310289,0.00006933996,0.0006626516,0.00005569545,0.001877169],"genre_scores_gemma":[0.9784371,0.001887557,0.01215423,0.00004788527,0.00002130151,0.0001869929,0.001867179,0.00002908998,0.005368696],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001365388,"threshold_uncertainty_score":0.004567683,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06783047413923046,"score_gpt":0.4461762365337316,"score_spread":0.3783457623945011,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}