{"id":"W2752200415","doi":"10.1194/jlr.m079822","title":"Polygenic determinants in extremes of high-density lipoprotein cholesterol","year":2017,"lang":"en","type":"article","venue":"Journal of Lipid Research","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute; Western University","funders":"Canadian Institutes of Health Research; Genome Canada","keywords":"High-density lipoprotein; Cholesterol; Ldl cholesterol; Biology; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006843686,0.0001152815,0.0007464596,0.00051605,0.0001956923,0.00005492587,0.0004759223,0.0001452172,0.00004580673],"category_scores_gemma":[0.001286642,0.00008404129,0.0003179567,0.0001648194,0.0002425735,0.0002282919,0.0001933215,0.001022673,0.00001286751],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001463523,"about_ca_system_score_gemma":0.0006156709,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004612067,"about_ca_topic_score_gemma":0.000723475,"domain_scores_codex":[0.9965575,0.0003515779,0.0007039076,0.0001816066,0.001755179,0.0004502679],"domain_scores_gemma":[0.9973682,0.00006587399,0.0004496399,0.001023366,0.0008057503,0.0002871342],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.001825348,0.0007257612,0.2116485,0.0008894723,0.0002612273,0.001266213,0.0005125362,0.000002279168,0.03819061,0.0000410757,0.0006337984,0.7440032],"study_design_scores_gemma":[0.003382384,0.001005511,0.9375769,0.0009442563,0.00002820343,0.0006129828,0.0001208842,0.00002382201,0.0552021,0.0001934488,0.0008368801,0.00007256454],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962839,0.0007805345,0.00002437774,0.001888409,0.0002688033,0.0004144444,0.000001902787,0.000002948978,0.0003346564],"genre_scores_gemma":[0.9970832,0.0007072438,0.0003726287,0.0000283134,0.001361834,0.000005443156,2.203616e-7,0.0000205423,0.0004205053],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7439306,"threshold_uncertainty_score":0.6972097,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09072979962759084,"score_gpt":0.4064531741176594,"score_spread":0.3157233744900685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}