{"id":"W2752214746","doi":"10.1038/nature23666","title":"Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy","year":2017,"lang":"en","type":"article","venue":"Nature","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":418,"is_retracted":false,"has_abstract":false,"ca_institutions":"Alberta Children's Hospital; Canada's Michael Smith Genome Sciences Centre; St. Michael's Hospital; Structural Genomics Consortium; Ontario Institute for Cancer Research; Terry Fox Research Institute; University of Toronto; University Health Network; SickKids Foundation; BC Cancer Agency; University of Calgary; Princess Margaret Cancer Centre; Toronto Western Hospital; University of British Columbia; Hospital for Sick Children","funders":"Medical Research Council; Stand Up To Cancer; Government of Canada; Pfizer; Hospital for Sick Children; Wellcome Trust; Canadian Institutes of Health Research; Canada's Michael Smith Genome Sciences Centre; Genome Canada; American Association for Cancer Research; Eli Lilly and Company; Government of Ontario","keywords":"Biology; Stem cell; Cancer stem cell; Cancer research; Carcinogenesis; Population; Glioblastoma; Progenitor cell; Epigenetics; Neural stem cell; Cell biology; Genetics; Cancer; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000136892,0.0001107661,0.0001393248,0.00003349345,0.0001831967,0.00005359237,0.0004206706,0.0006179315,0.000009425586],"category_scores_gemma":[0.0000342104,0.0001086986,0.00006448437,0.00002313151,0.0000631099,0.000004733634,0.00018858,0.0003631142,0.000002570757],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001060838,"about_ca_system_score_gemma":0.00006117608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003442773,"about_ca_topic_score_gemma":0.0001053717,"domain_scores_codex":[0.9993147,0.00002197588,0.0001518483,0.0002542039,0.00009301248,0.0001643199],"domain_scores_gemma":[0.9988934,0.000007437675,0.00018923,0.0007418154,0.00009088082,0.00007718649],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004029681,0.00004383922,0.002261298,0.00003907533,0.00001843026,0.000008595046,0.0000677125,0.000008970303,0.9921659,0.000861629,0.003149447,0.001334838],"study_design_scores_gemma":[0.0007876938,0.0005773375,0.02074421,0.00004413755,0.00001885858,0.000007167809,0.00008085252,0.00002275663,0.938556,0.0006373823,0.03826251,0.000261089],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942263,0.001024173,0.00005240696,0.0001334289,0.0002053771,0.0001131168,0.00008201593,0.000005109432,0.004158068],"genre_scores_gemma":[0.9981482,0.0001269447,0.0003182676,0.0003485138,0.0003340791,0.000004866822,0.00004259957,0.00001852898,0.000657996],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05360987,"threshold_uncertainty_score":0.4766054,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01163397115629346,"score_gpt":0.2657177635625192,"score_spread":0.2540837924062258,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}