{"id":"W2752214746","doi":"10.1038/nature23666","title":"Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy","year":2017,"lang":"en","type":"article","venue":"Nature","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":418,"is_retracted":false,"has_abstract":false,"ca_institutions":"Alberta Children's Hospital; Canada's Michael Smith Genome Sciences Centre; St. Michael's Hospital; Structural Genomics Consortium; Ontario Institute for Cancer Research; Terry Fox Research Institute; University of Toronto; University Health Network; SickKids Foundation; BC Cancer Agency; University of Calgary; Princess Margaret Cancer Centre; Toronto Western Hospital; University of British Columbia; Hospital for Sick Children","funders":"Medical Research Council; Stand Up To Cancer; Government of Canada; Pfizer; Hospital for Sick Children; Wellcome Trust; Canadian Institutes of Health Research; Canada's Michael Smith Genome Sciences Centre; Genome Canada; American Association for Cancer Research; Eli Lilly and Company; Government of Ontario","keywords":"Biology; Stem cell; Cancer stem cell; Cancer research; Carcinogenesis; Population; Glioblastoma; Progenitor cell; Epigenetics; Neural stem cell; Cell biology; Genetics; Cancer; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000824469,0.00006886511,0.0001203002,0.0003622328,0.0001737881,0.0004177853,0.00009854711,0.0001117452,0.0007710232],"category_scores_gemma":[0.0001205149,0.00009376146,0.00007676781,0.0002078855,0.0001721364,0.0001345656,0.0001968184,0.0002427382,0.0002384587],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002038697,"about_ca_system_score_gemma":0.0002400061,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001834228,"about_ca_topic_score_gemma":0.002774702,"domain_scores_codex":[0.9999518,0.000004684523,0.000002384838,0.000009237599,0.00001775969,0.00001405847],"domain_scores_gemma":[0.9999329,0.00001434729,0.0000115451,0.00001125532,0.00001472159,0.00001517621],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001065415,0.00001268463,0.002400943,0.00001376245,0.000003765998,0.00005418398,0.00008687591,0.0001577375,0.9896651,0.00164127,0.00007629071,0.005780813],"study_design_scores_gemma":[0.00002931409,0.0001878998,0.06645753,0.00001093549,0.00003188321,0.0007341427,0.0003343892,0.003199466,0.9221088,0.001482445,0.005415671,0.000007538382],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948137,0.000269971,0.002586323,0.00004171644,0.000003747601,0.000009180339,0.0002165041,0.00004009257,0.002018758],"genre_scores_gemma":[0.9969283,0.0001670085,0.001058077,0.00002503528,0.00000174779,0.000008707023,0.0002103966,0.00002024179,0.001580383],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001834228,"threshold_uncertainty_score":0.003647089,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01163397115629346,"score_gpt":0.2657177635625192,"score_spread":0.2540837924062258,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}