{"id":"W2752270341","doi":"10.1186/s12981-017-0174-7","title":"A novel HIV vaccine targeting the protease cleavage sites","year":2017,"lang":"en","type":"review","venue":"AIDS Research and Therapy","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Science Centre for Human and Animal Health; Occupational and Environmental Medical Association of Canada; Public Health Agency of Canada; University of Manitoba","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Immune system; Protease; HIV vaccine; Human immunodeficiency virus (HIV); Medicine; Immunity; Virology; Limiting; Immunology; HIV-1 protease; Cleavage (geology); Biology; Vaccine trial; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003256,0.0007138923,0.0007498962,0.001387527,0.000191543,0.0007165215,0.0006777388,0.001049486,0.002307977],"category_scores_gemma":[0.0002510893,0.0002304133,0.0003656003,0.0009429618,0.000391325,0.0009945186,0.0006039033,0.001832022,0.001694159],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004699436,"about_ca_system_score_gemma":0.0005455155,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005024222,"about_ca_topic_score_gemma":0.000922052,"domain_scores_codex":[0.9998981,0.00001407644,0.00001044191,0.00001826144,0.00004301894,0.00001610631],"domain_scores_gemma":[0.9999287,0.0000224869,0.00001616306,0.000003153836,0.00001850815,0.00001090589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000493728,0.0001004243,0.0001297612,0.007818461,0.00005097525,0.0001835975,0.00003707789,0.0002909102,0.009305807,0.004473323,0.0255131,0.9520472],"study_design_scores_gemma":[0.00001309779,0.0001006736,0.0003991088,0.001044187,0.00004537402,0.001217825,0.00002258455,0.0000718197,0.002386791,0.00113075,0.9935545,0.00001329324],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003487932,0.9970285,0.0003807855,0.0003051957,0.0002961443,0.00001099487,0.00002111195,0.00001575252,0.001592662],"genre_scores_gemma":[0.002042807,0.9950766,0.0004429824,0.0003490466,0.0001692522,0.00001663247,0.00005607098,0.000002738208,0.001843829],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002307977,"threshold_uncertainty_score":0.007720947,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1906609999740229,"score_gpt":0.4375860536650094,"score_spread":0.2469250536909865,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}