{"id":"W2752302055","doi":"10.1099/jgv.0.000905","title":"Two common variants of human papillomavirus type 16 E6 differentially deregulate sugar metabolism and hypoxia signalling in permissive human keratinocytes","year":2017,"lang":"en","type":"article","venue":"Journal of General Virology","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"NOSM University; Lakehead University; Thunder Bay Regional Research Institute","funders":"","keywords":"Biology; Kinase; Phenotype; Cancer research; Protein kinase A; Hypoxia (environmental); Population; Cell biology; Genetics; Warburg effect; Cancer cell; Cancer; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003126664,0.0002215146,0.0006530877,0.0001231941,0.0002215373,0.00005142575,0.000393937,0.0002116136,0.00004816631],"category_scores_gemma":[0.00005950701,0.0001937093,0.000145817,0.00002916173,0.0002463755,0.0000200145,0.0001850785,0.0002414386,5.385549e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001359256,"about_ca_system_score_gemma":0.00007205681,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003138352,"about_ca_topic_score_gemma":0.0008588557,"domain_scores_codex":[0.9984841,0.0001932421,0.0006230126,0.0002567205,0.0001508598,0.0002920087],"domain_scores_gemma":[0.9985197,0.00001343814,0.0008264353,0.0003423171,0.00016916,0.0001289791],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000307373,0.00008377124,0.004392977,0.00001320301,0.0001586386,0.00001657094,0.00008321121,0.00006686543,0.9921365,0.0006396622,0.000193625,0.001907568],"study_design_scores_gemma":[0.004694513,0.0008703042,0.4668913,0.00003592892,0.0002187092,0.0001754957,0.0000297712,0.00003895426,0.5211248,0.002427836,0.003182736,0.0003096642],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912527,0.007427234,0.00006011601,0.0000915171,0.0007689155,0.00009741316,0.00001101954,0.00000221057,0.0002888415],"genre_scores_gemma":[0.9956561,0.001591441,0.0003963634,0.0001482566,0.001834752,0.000002159735,0.00001599067,0.00002638545,0.0003284933],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4710117,"threshold_uncertainty_score":0.7899236,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01992235473634452,"score_gpt":0.3004929737876181,"score_spread":0.2805706190512736,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}