{"id":"W2752319470","doi":"10.1186/s13148-017-0390-y","title":"Efficacy of EZH2 inhibitory drugs in human papillomavirus-positive and human papillomavirus-negative oropharyngeal squamous cell carcinomas","year":2017,"lang":"en","type":"article","venue":"Clinical Epigenetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta Hospital; Alberta Hospital Edmonton; University of Alberta","funders":"University Hospital Foundation; University of Alberta","keywords":"EZH2; Cancer research; Cell culture; Histone methyltransferase; Biology; Epigenetics; Cell growth; Methyltransferase; Histone H3; Cell; Methylation; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002944376,0.0002867321,0.0005082146,0.000314435,0.00011922,0.0002544376,0.0002105321,0.0002085848,0.001577928],"category_scores_gemma":[0.0002445788,0.0001069983,0.0002890106,0.0002253731,0.0001790742,0.0002117408,0.000157676,0.0004088448,0.0001753447],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002333691,"about_ca_system_score_gemma":0.0002144082,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006544337,"about_ca_topic_score_gemma":0.00141048,"domain_scores_codex":[0.9998525,0.00003813638,0.00002046845,0.00002067365,0.00004004418,0.00002802723],"domain_scores_gemma":[0.9998946,0.00003234353,0.00001910047,0.00001105866,0.00001552598,0.00002744085],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007990534,0.00139174,0.005963628,0.0005546839,0.0002787063,0.0002102283,0.00007326791,0.0007160496,0.922989,0.0001885224,0.0004645745,0.05917902],"study_design_scores_gemma":[0.0008131586,0.02247147,0.05545029,0.00002853599,0.0005674505,0.0006956123,0.0001018362,0.001021483,0.9115735,0.00006185532,0.007200532,0.00001426309],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992313,0.00555953,0.0002584156,0.00005515462,0.000030387,0.00004512262,0.0002343035,0.00003252264,0.001471559],"genre_scores_gemma":[0.9955897,0.002688625,0.0002910737,0.00003249973,0.00001196895,0.00003221113,0.0004887031,0.000006296803,0.0008589601],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001577928,"threshold_uncertainty_score":0.005278647,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03021418371202986,"score_gpt":0.3512143170447681,"score_spread":0.3210001333327382,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}