{"id":"W2752319470","doi":"10.1186/s13148-017-0390-y","title":"Efficacy of EZH2 inhibitory drugs in human papillomavirus-positive and human papillomavirus-negative oropharyngeal squamous cell carcinomas","year":2017,"lang":"en","type":"article","venue":"Clinical Epigenetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta Hospital; Alberta Hospital Edmonton; University of Alberta","funders":"University Hospital Foundation; University of Alberta","keywords":"EZH2; Cancer research; Cell culture; Histone methyltransferase; Biology; Epigenetics; Cell growth; Methyltransferase; Histone H3; Cell; Methylation; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008853215,0.0003607629,0.0006592967,0.00008777811,0.0004286761,0.00006596869,0.0005057182,0.0005387683,0.00001766983],"category_scores_gemma":[0.0006138736,0.00037195,0.0002435539,0.00006493034,0.001061316,0.00001170545,0.0005381078,0.0003798889,0.000005822164],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002571987,"about_ca_system_score_gemma":0.0001071961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004489431,"about_ca_topic_score_gemma":0.0003138588,"domain_scores_codex":[0.9968663,0.0003952281,0.001196818,0.0008395307,0.0002717821,0.0004303497],"domain_scores_gemma":[0.9973961,0.0002858058,0.0007565112,0.00109366,0.0002035792,0.000264382],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002449078,0.0007455447,0.3986233,0.00006678098,0.00004791639,0.00001776236,0.0003693145,0.00005923818,0.5913427,0.0001891721,0.00006710505,0.008226287],"study_design_scores_gemma":[0.003029108,0.001407766,0.5798976,0.00003384834,0.00005121138,4.192856e-7,0.00005383741,0.00001934677,0.4139163,0.000731841,0.0005420887,0.000316648],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926808,0.002638005,0.00006610789,0.0000431529,0.0002606835,0.0004875917,0.00006108513,0.00001011907,0.00375242],"genre_scores_gemma":[0.9972939,0.00102114,0.0005628793,0.00007032525,0.0005149152,0.00001675865,0.00007983271,0.00006082794,0.0003794478],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1812743,"threshold_uncertainty_score":0.9998732,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03021418371202986,"score_gpt":0.3512143170447681,"score_spread":0.3210001333327382,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}