{"id":"W2752388200","doi":"10.1016/j.canlet.2017.08.037","title":"Role of cellular metabolism in regulating type I interferon responses: Implications for tumour immunology and treatment","year":2017,"lang":"en","type":"review","venue":"Cancer Letters","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"Carleton University","funders":"","keywords":"Immune system; Immunology; Immunosuppression; Interferon; Biology; Pathogenesis; Autoimmunity; Cancer; Interferon type I; Cancer research; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008605599,0.0001994873,0.001045061,0.0002307872,0.00006126978,0.00001302485,0.00009216113,0.0001026564,0.00001938341],"category_scores_gemma":[0.00007549838,0.0001583472,0.0002163137,0.00007099273,0.00007059435,0.00003462893,0.00002900471,0.0001474185,0.000001678579],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002377959,"about_ca_system_score_gemma":0.0002335371,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002427944,"about_ca_topic_score_gemma":0.00003316658,"domain_scores_codex":[0.9990911,0.00004258727,0.0004063864,0.0002671036,0.00003349404,0.0001592585],"domain_scores_gemma":[0.9990279,0.0001324677,0.0003678366,0.0003784869,0.0000572303,0.0000360417],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001843293,0.00004633763,0.00003734595,0.001283187,0.0003651259,0.000001857493,0.0002374097,0.000001066228,0.2355229,0.0001162827,0.0002376958,0.7619664],"study_design_scores_gemma":[0.0005553912,0.0002009466,0.0004490663,0.005663278,0.0009476438,0.0000218455,0.0000244579,0.000005799592,0.002472036,0.00001333449,0.9895157,0.0001304901],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.008550374,0.9893293,0.00003462737,0.0007908049,0.000215016,0.0008617497,0.0001470371,0.00001141088,0.00005967759],"genre_scores_gemma":[0.005863423,0.9927074,0.0001898894,0.00007932322,0.0002538559,0.0005566998,0.0001071054,0.00004045683,0.000201876],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.989278,"threshold_uncertainty_score":0.6457211,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1202146857757062,"score_gpt":0.4025911449529095,"score_spread":0.2823764591772032,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}