{"id":"W2752445480","doi":"10.1016/j.bbrc.2017.08.137","title":"Zinc binds non-cooperatively to human liver metallothionein 2a at physiological pH","year":2017,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Trace Elements in Health","field":"Nursing","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Metallothionein; Chemistry; Zinc; Cysteine; Biochemistry; Enzyme; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003694014,0.0002687013,0.0005125219,0.0002968079,0.0004994248,0.0004560906,0.000524937,0.0004618752,0.002537956],"category_scores_gemma":[0.001037059,0.0003313188,0.0003069414,0.000267403,0.0003548992,0.0001704672,0.0004477536,0.0004791486,0.0008998922],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005942057,"about_ca_system_score_gemma":0.0003485603,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003623483,"about_ca_topic_score_gemma":0.005473076,"domain_scores_codex":[0.9995315,0.0001090626,0.00002130747,0.0001159335,0.0001084892,0.0001137702],"domain_scores_gemma":[0.9994081,0.0003024223,0.00007258778,0.00005667085,0.00006851121,0.00009168546],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002383945,0.00008818797,0.001799319,0.0001471965,0.00004251769,0.000136545,0.0001289847,0.0001527298,0.99283,0.00006216027,0.0003947786,0.001833756],"study_design_scores_gemma":[0.0001801573,0.0006275026,0.03604263,0.00001775799,0.00004222498,0.0004852033,0.0002040342,0.001785028,0.9571686,0.0001614733,0.003258105,0.00002719563],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922816,0.002911238,0.002094753,0.0002124384,0.00007795075,0.00003951546,0.0002081547,0.00009677204,0.002077605],"genre_scores_gemma":[0.9969546,0.0002652338,0.0005087576,0.00006478791,0.00001793815,0.00001529328,0.0003083904,0.00001284117,0.001852136],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003623483,"threshold_uncertainty_score":0.008490324,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2499550716406334,"score_gpt":0.4778887902448769,"score_spread":0.2279337186042435,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}