{"id":"W2752566204","doi":"10.1093/ofid/ofx163.757","title":"Persistence of Bactericidal Activity at 4 Years After 2 Primary Doses of a Recombinant, 4-Component, Meningococcal Serogroup B Vaccine (4CMenB) and Response to a Booster Dose in Adolescents and Young Adults","year":2017,"lang":"en","type":"article","venue":"Open Forum Infectious Diseases","topic":"Bacterial Infections and Vaccines","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Sanofi Pasteur; Novavax; Sanofi; GlaxoSmithKline; Pfizer","keywords":"Medicine; Booster dose; Meningococcal vaccine; Vaccination; Titer; Group B; Meningococcal disease; Persistence (discontinuity); Pediatrics; Immunology; Neisseria meningitidis; Internal medicine; Antigen; Antibody; Immunization; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001947666,0.0001916492,0.0004526761,0.000149365,0.0002279782,0.00007909156,0.0002068558,0.0001145294,0.00008217918],"category_scores_gemma":[0.0001093209,0.0001777168,0.00006822556,0.00007021845,0.0001204613,0.0004404912,0.001019853,0.0001001967,0.000007732549],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006588618,"about_ca_system_score_gemma":0.00003580358,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002065738,"about_ca_topic_score_gemma":0.001785253,"domain_scores_codex":[0.998854,0.000222554,0.0002715051,0.0003565198,0.00002369067,0.0002717739],"domain_scores_gemma":[0.9991897,0.00005777633,0.0002486316,0.0003864096,0.00005333924,0.00006409424],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0176695,0.000506038,0.7710084,0.00007815786,0.00005616075,0.000004538399,0.0003454075,1.364278e-7,0.2054293,0.000002253086,0.00006807438,0.004831941],"study_design_scores_gemma":[0.004764364,0.0008343689,0.9900057,0.0004356237,0.00005471555,0.0000671684,0.00009397825,0.000001133503,0.00320811,0.00001171113,0.0003350453,0.000188045],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982988,0.0002842914,0.000001055166,0.0001153784,0.0004165725,0.0006812328,0.00009752668,0.0000143643,0.00009081604],"genre_scores_gemma":[0.9995855,0.00007536876,0.00000764159,0.00004014631,0.000007825561,0.00009437498,0.00001308452,0.0000162182,0.0001598148],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2189973,"threshold_uncertainty_score":0.7247081,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01007633261890411,"score_gpt":0.2501282993574245,"score_spread":0.2400519667385204,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}