{"id":"W2752588133","doi":"10.1021/acs.biomac.7b00994","title":"A Polymer Therapeutic Having Universal Heparin Reversal Activity: Molecular Design and Functional Mechanism","year":2017,"lang":"en","type":"article","venue":"Biomacromolecules","topic":"Proteoglycans and glycosaminoglycans research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Michael Smith Health Research BC","keywords":"Chemistry; Heparin; Protamine; Antidote; Biophysics; Steric effects; Antithrombin; Isothermal titration calorimetry; Combinatorial chemistry; Stereochemistry; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001636543,0.0003703013,0.0001507867,0.0001514743,0.0001107741,0.0002190902,0.0002576942,0.000472261,0.0005320355],"category_scores_gemma":[0.0001353448,0.0001301608,0.0002077123,0.0001294899,0.0002016482,0.0004119826,0.0001966357,0.0004849695,0.0003139237],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003490722,"about_ca_system_score_gemma":0.0001849575,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002121921,"about_ca_topic_score_gemma":0.0001658861,"domain_scores_codex":[0.9999108,0.00001415057,0.000008520414,0.00002314967,0.0000236991,0.00001966717],"domain_scores_gemma":[0.9999453,0.000004870571,0.00002096347,0.000004886166,0.000008905097,0.00001505772],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008525282,0.00005994471,0.0000974584,0.0001531441,0.000007103443,0.00006912456,0.00001716258,0.0003519691,0.9871261,0.001635758,0.0001388031,0.01025833],"study_design_scores_gemma":[0.00004111811,0.001010497,0.0006203863,0.0000116816,0.00002174406,0.0003806813,0.000007655147,0.001942574,0.9791014,0.0002129605,0.01663517,0.00001417677],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8913779,0.01611822,0.07830592,0.001367345,0.0002249151,0.0007720874,0.000601039,0.0003547578,0.01087792],"genre_scores_gemma":[0.941994,0.006785008,0.04571592,0.0004061289,0.00006489948,0.0002949782,0.0003354401,0.00003255627,0.004371027],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005320355,"threshold_uncertainty_score":0.002532721,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0284415108870086,"score_gpt":0.2760958630689437,"score_spread":0.2476543521819351,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}