{"id":"W2752588133","doi":"10.1021/acs.biomac.7b00994","title":"A Polymer Therapeutic Having Universal Heparin Reversal Activity: Molecular Design and Functional Mechanism","year":2017,"lang":"en","type":"article","venue":"Biomacromolecules","topic":"Proteoglycans and glycosaminoglycans research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Michael Smith Health Research BC","keywords":"Chemistry; Heparin; Protamine; Antidote; Biophysics; Steric effects; Antithrombin; Isothermal titration calorimetry; Combinatorial chemistry; Stereochemistry; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002457582,0.0002483224,0.0001824858,0.00008244772,0.0005633864,0.0002207063,0.0003534975,0.0002044878,0.00003000428],"category_scores_gemma":[0.00005378672,0.0002433655,0.00009916045,0.00004761349,0.0003081274,0.00001944116,0.0004194851,0.0001253023,0.00001024308],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002663663,"about_ca_system_score_gemma":0.0001594297,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002860984,"about_ca_topic_score_gemma":0.00003338661,"domain_scores_codex":[0.9984763,0.0001383424,0.0001216576,0.0005781997,0.0002601846,0.0004253024],"domain_scores_gemma":[0.9989505,0.00001432182,0.0001073315,0.0006860077,0.00007220932,0.0001696646],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003161531,0.00005287013,0.0002158938,0.00001247484,0.0001291325,0.0001042014,0.0000148529,0.000002564367,0.9861915,0.002201784,0.0001433107,0.01061524],"study_design_scores_gemma":[0.0009020086,0.0003335237,0.003922817,0.00001680579,0.00003496012,0.0001010161,0.0000238696,0.0004771986,0.991926,0.0005660391,0.00137422,0.0003215617],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8232937,0.001013253,0.1740536,0.0006408416,0.0001196761,0.0003337731,0.00002336503,0.00002322213,0.0004985271],"genre_scores_gemma":[0.9966746,0.000127792,0.001909781,0.0001453329,0.00009175797,0.00003560408,0.0000228203,0.00004095764,0.0009513595],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1733809,"threshold_uncertainty_score":0.9924157,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0284415108870086,"score_gpt":0.2760958630689437,"score_spread":0.2476543521819351,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}