{"id":"W2752712408","doi":"10.1093/infdis/jix470","title":"Evaluating the Impact of Functional Genetic Variation on HIV-1 Control","year":2017,"lang":"en","type":"article","venue":"The Journal of Infectious Diseases","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Manitoba; Public Health Agency of Canada","funders":"National Center for Advancing Translational Sciences; National Institute of Allergy and Infectious Diseases; University of California, San Francisco; Center for AIDS Research, University of Washington; National Center for Research Resources; Medical Research Council; ACT Government; Harvard University Center for AIDS Research; AIDS Clinical Trials Group; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Biology; Genetics; Gene; Genotyping; Genetic variation; Human leukocyte antigen; Genetic association; Major histocompatibility complex; Exome; Genome; Allele; CRISPR; Exome sequencing; Single-nucleotide polymorphism; Genotype; Computational biology; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00179557,0.0003854464,0.0003169831,0.0008669288,0.0002923835,0.0005687799,0.0004347932,0.0004535749,0.002489404],"category_scores_gemma":[0.003690012,0.00009285133,0.0003990202,0.0008505905,0.0005327863,0.0002800352,0.0003615346,0.0004504905,0.0001163662],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002658478,"about_ca_system_score_gemma":0.0002234575,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001081005,"about_ca_topic_score_gemma":0.001223455,"domain_scores_codex":[0.9989253,0.000416571,0.00007770293,0.0003057722,0.0001851958,0.00008941966],"domain_scores_gemma":[0.9969006,0.00217051,0.0004149475,0.0002409741,0.0001239423,0.000149017],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00160448,0.0001022331,0.9322795,0.0001595101,0.001241723,0.0006327986,0.000269514,0.00186813,0.03289717,0.0007972827,0.0001716678,0.02797601],"study_design_scores_gemma":[0.00003672486,0.0006117624,0.9825752,0.00003355923,0.0006442136,0.001199048,0.0001427186,0.003267678,0.008992931,0.001441535,0.001039298,0.00001543238],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964427,0.000867927,0.001593244,0.0000598716,0.000007951825,0.00001196164,0.0003511538,0.000008021907,0.0006571781],"genre_scores_gemma":[0.9990772,0.000130021,0.0004976026,0.00002794819,0.000006797793,0.000006311236,0.0001728102,0.00000470008,0.00007662644],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002489404,"threshold_uncertainty_score":0.009496033,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02929683329129165,"score_gpt":0.3441682356197065,"score_spread":0.3148714023284149,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}